一般人群中尿蛋白水平对主要不良心脑血管事件及全因死亡的影响
发布时间:2018-08-08 10:51
【摘要】:目的研究一般人群中尿蛋白水平对主要不良心脑血管事件(MACCE)及全因死亡的影响。方法采用前瞻性队列研究方法,入选2006年7月至2007年10月参加开滦集团健康体检人群中资料完整者共87292例作为研究对象,平均年龄51.12±12.29岁。采用尿常规试纸法检测晨尿,以尿蛋白水平分为3组:尿蛋白阴性组(-)、微量尿蛋白组(±/+)、大量尿蛋白组(≥2+)。应用COX比例风险模型分析尿蛋白与MACCE及全因死亡的关系。结果平均随访6.90±0.72年,随访期间共发生MACCE 3091例,累积发病率为5.25/千人年;全因死亡事件4087例,累积发病率为6.84/千人年。3组MACCE累积发病率分别为4.84/千人年、7.34/千人年、12.06/千人年;全因死亡率分别为6.10/千人年、10.28/千人年、19.30/千人年,差异均具有统计学意义(P0.01)。校正其他传统危险因素后,与尿蛋白阴性组相比,微量尿蛋白组、大量尿蛋白组发生MACCE的RR值分别为1.24(95%CI 1.10~1.40)、1.58(95%CI 1.38~1.81),全因死亡的RR值分别为1.41(95%CI 1.27~1.56)、2.15(95%CI 1.93~2.39)。结论尿常规显示的尿蛋白是一般人群MACCE及全因死亡的独立危险因素。
[Abstract]:Objective to study the effect of urinary protein level on (MACCE) and all-cause death of major adverse cardiovascular and cerebrovascular events in general population. Methods A prospective cohort study was used to study the data of 87292 people who participated in Kailuan Group health check-up from July 2006 to October 2007. The average age was 51.12 卤12.29 years old. Morning urine was detected by urine routine test paper. Urine protein levels were divided into 3 groups: negative urine protein group (-), microurinary protein group (卤/), and large urine protein group (鈮,
本文编号:2171566
[Abstract]:Objective to study the effect of urinary protein level on (MACCE) and all-cause death of major adverse cardiovascular and cerebrovascular events in general population. Methods A prospective cohort study was used to study the data of 87292 people who participated in Kailuan Group health check-up from July 2006 to October 2007. The average age was 51.12 卤12.29 years old. Morning urine was detected by urine routine test paper. Urine protein levels were divided into 3 groups: negative urine protein group (-), microurinary protein group (卤/), and large urine protein group (鈮,
本文编号:2171566
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