转移性肾细胞癌中RSK4、CD44及MMP-9的表达及意义

发布时间：2018-08-13 21:42

【摘要】：目的检测核糖体S6蛋白激酶4(ribosomal S6 protein kinase 4,RSK4)、CD44和MMP-9在原发性肾细胞癌(primary renal cell carcinoma,pRCC)及转移性肾细胞癌(metastatic renal cell carcinoma,mRCC)中的表达,探讨三者表达水平及与临床病理特征的相关性。方法采用免疫组化En Vision法检测52例pRCC及48例mRCC中RSK4、MMP-9和CD44蛋白的表达,并分析三者表达的相关性及与临床病理特征的关系。结果 48例mRCC中RSK4、CD44及MMP-9的阳性率分别为75%(36/48)、68.75%(33/48)及91.7%(44/48),而三者在52例pRCC中的阳性率分别为44.2%(23/52)、34.6%(18/52)及69.2%(36/52)。RSK4、CD44及MMP-9在mRCC中的表达高于pRCC(PRSK4=0.002;PMMP-9=0.002;PCD44=0.001);RSK4、CD44及MMP-9表达与mRCC患者年龄、性别和肿瘤Fuhrman分级、转移部位之间未见明确相关性(P0.05)。在mRCC中,三者之间的表达呈正相关(P=0.008);两两相关分析发现RSK4与CD44(P=0.019)、MMP-9与CD44(P=0.05)的表达之间存在正相关,而RSK4与MMP-9(P=1.00)未见明确相关性。结论 RSK4、CD44及MMP-9在mRCC中的表达高于pRCC,提示三者可能介导肾细胞癌(renal cell carcinoma,RCC)的转移,而其具体作用机制尚有待进一步研究。
[Abstract]:Objective to detect the expression of ribosomal S6 protein kinase 4 (ribosomal S6 protein kinase 4) CD44 and MMP-9 in primary renal cell carcinoma (primary renal cell carcinoma pRCC) and metastatic renal cell carcinoma (metastatic renal cell carcinoma mRCC), and to explore the relationship between the expression of CD44 and MMP-9 and the clinicopathological features. Methods Immunohistochemical en Vision method was used to detect the expression of RSK4MMP 9 and CD44 in 52 cases of pRCC and 48 cases of mRCC, and the relationship between the expression of them and clinicopathological features was analyzed. 缁撴灉 48渚媘RCC涓璕SK4,CD44鍙奙MP-9鐨勯槼鎬х巼鍒嗗埆涓，

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