男性继发不育患者临床特点分析

发布时间：2018-08-27 17:06

【摘要】：目的调查二胎生育男性不育症患者的基本临床特点。方法选取北京协和医院和北京市仁和医院男科门诊就诊的男性不育患者410例,其中一胎不育患者(A组)264例,二胎不育患者(B组)146例,采用门诊问卷收集患者的一般信息和精液分析数据,并采用勃起功能国际问卷5(IIEF-5)调查患者的勃起功能状况。结果在调查的410例男性不育患者中,A组、B组患者的年龄分别是(31.3±5.4)岁和(39.5±4.8)岁(P0.01);合并一种以上慢性疾病(糖尿病、高血压、前列腺疾病)的发生率分别是14.8%(39/264)和24.7%(36/146)(P0.05);每月性交次数分别为(9.7±1.2)次和(6.5±1.4)次(P0.01);勃起功能障碍(ED)的发生率分别为50.8%(134/264)和70.5%(103/146)(P0.01),其中B组不育者的重度ED发生率为10.3%,明显高于A组不育者的1.1%(P0.01);A组的精子浓度[(39.7±10.6)×10~6/m L]高于B组[(34.6±8.5)×10~6/m L](P0.01),但A组的精子总数[(114.3±33.4)×10~6]少于B组[(150.4±41.1)×10~6](P0.01);A组的a级精子活力12.6%±5.5%高于B组的8.5%±3.2%(P0.01),两者在前向运动精子(a+b)及精子总活动(a+b+c)率方面没有统计学差异。结论二胎生育男性不育患者具有年龄大、合并慢性疾病多、性交次数少、易发生E D、精子质量尚可的特点,临床诊疗工作要给予必要的关注和进行相应的调整。
[Abstract]:Objective to investigate the basic clinical features of infertile men with second birth. Methods 410 male infertile patients were selected from Peking Union Hospital and Renhe Hospital, including 264 cases of one-child infertility (group A) and 146 cases of second-born infertility (group B). The data of general information and semen analysis were collected by outpatient questionnaire, and erectile function was investigated by International questionnaire of erectile function (IIEF-5). Results the age of the patients in group A and group B were (31.3 卤5.4) years old and (39.5 卤4.8) years old (P0.01) respectively, and the patients were complicated with more than one chronic disease (diabetes mellitus, hypertension), the age of group B was (31.3 卤5.4) years old and (39.5 卤4.8) years old (P0.01). The incidence of prostatic diseases was 14.8% (39 / 264) and 24.7% (36 / 146) respectively (P0.05), the number of sexual intercourse per month was (9.7 卤1.2) and (6.5 卤1.4) (P0.01), the incidence of erectile dysfunction (ED) was 50.8% (134264 / 264) and 70.5% (103r146) (P0.01) respectively. The incidence of severe ED in group B was 10.3%, which was significantly higher than that in group A (P 0.01). The sperm concentration in group A [(39.7 卤10.6) 脳 10 ~ (-6) / mL] was higher than that in group B [(34.6 卤8.5) 脳 10 ~ (6) / mL] (P0.01), but the total sperm count in group A [(114.3 卤33.4) 脳 10 ~ (6) 脳 10 ~ (6)] was lower than that in group B [(150.4 卤41.1) 脳 10 ~ (6) 脳 10 ~ (6)] (P _ (0.01). The sperm motility of group A was 12.6% 卤5.5% higher than that of group B (8.5% 卤3.2%). The rate of (a b) and total motility of sperm in group A was significantly lower than that in group B [(150.4 卤41.1) 脳 10 ~ (6) 脳 10 ~ (6)] (P0.01). There is no statistical difference in the surface. Conclusion the male infertile patients with second birth have the characteristics of older age, more chronic diseases, less sexual intercourse, easy to develop E D, and good sperm quality. The clinical diagnosis and treatment should be paid attention to and adjusted accordingly.
【作者单位】：中国医学科学院北京协和医院泌尿外科;山东省交通医院;北京市仁和医院男科;
【基金】：国家自然科学基金面上项目(81370698;81671448) 北京市自然科学基金资助项目(7162152)~~
【分类号】：R698.2

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