精浆AMH、INHB、血清INHB对常规IVF受精结局的预测价值

发布时间：2018-09-01 17:50

【摘要】：目的:分析精浆AMH、INHB及血清INHB与少弱精子症患者精液参数之间的相关性,同时探讨对其常规体外受精(IVF)结局的预测价值及影响。方法:收集2016年8月至2017年2月因男方少弱精子症或女方输卵管因素就诊于宁夏医科大学总医院生殖中心行IVF助孕的88例不孕夫妇的临床资料,检测精浆AMH、INHB、血清INHB及精液参数(精子活动率、浓度、总数、前向运动精子百分率及正常形态精子百分率),采用受试者工作特征曲线(ROC)分析精浆AMH、INHB、血清INHB及精液参数对其受精率的预测能力;Pearson相关分析检验精浆AMH、INHB及血清INHB与精液参数之间的关系,均设定P0.05为有统计学差异。结果:精浆AMH:AUC=0.807(敏感度84.6%,特异度76.0%,截断点3.529,P=0.000),精浆INHB:AUC=0.768(敏感度84.6%,特异度88.7%,截断点31.117,P=0.002);血清INHB与精子浓度(r=0.346,P=0.001)、精子总数(r=0.378,P=0.000)、精子活动率(r=0.521,P=0.000)、前向运动(r=0.343,P=0.001)。结论:精浆AMH、INHB可作为预测少弱精子症患者受精率的实验室指标;血清INHB与少弱精子症精液参数(精子浓度、精子总数、活动率及前向运动精子百分率)呈显著正相关。
[Abstract]:Objective: to analyze the correlation between seminal plasma AMH,INHB and serum INHB and semen parameters of oligozoospermia patients, and to explore the predictive value and influence of seminal plasma AMH,INHB and serum INHB on the (IVF) outcome of routine in vitro fertilization. Methods: from August 2016 to February 2017, 88 infertile couples who were treated with IVF in the Reproductive Center of Ningxia Medical University General Hospital for oligozoospermia or female fallopian tube were collected. Seminal plasma AMH,INHB, serum INHB and semen parameters (sperm motility, sperm concentration, total number) were measured. Forward motility sperm percentage and normal sperm morphology). The predictive ability of seminal plasma AMH,INHB, serum INHB and semen parameters to the fertilization rate was analyzed by using the operating characteristic curve (ROC). Pearson correlation analysis was used to test the relationship between seminal plasma AMH,INHB and serum INHB. The relationship between semen parameters, All set P0.05 as a statistical difference. Results: seminal plasma AMH:AUC=0.807 (sensitivity 84.6, specificity 76.0), seminal plasma INHB:AUC=0.768 (sensitivity 84.6, specificity 88.7T, cut-off point 31.117P0. 002), serum INHB and sperm concentration (rr 0.344 P0. 001), total sperm count (r0. 378p 0. 000), sperm motility rate (rr 0. 521 P0. 000), forward motility (r 0. 343n P0. 001), seminal plasma INHB:AUC=0.768 (sensitivity 84. 6, specificity 88. 7, cutoff point 31. 117 P0. 002), total sperm count (r0. 378m P0. 000), sperm motility (rt0. 521 P0. 000), forward motility (r0. 343n P0. 001). Conclusion: seminal plasma AMH,INHB can be used as a laboratory index to predict fertilization rate of oligozoospermia patients, and serum INHB is positively correlated with semen parameters (sperm concentration, total sperm count, motility rate and forward motility sperm percentage) of oligozoospermia.
【作者单位】：宁夏医科大学研究生院妇产科学系;宁夏医科大学生育力保持教育部重点实验室;宁夏医科大学总医院生殖中心;
【基金】：国家自然科学基金(81660257) 宁夏自然科学基金重点项目(NZ16125) 宁夏回族自治区领军人才项目(2016) 宁夏回族自治区留学人员创新项目(2016) 2017年宁夏研究生创新计划项目~~
【分类号】：R698.2

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