中频穴位电刺激联合他莫昔芬片治疗少弱精子症患者的临床研究
发布时间：2018-09-05 09:06
【摘要】：目的:探讨中频穴位电刺激联合他莫昔芬片治疗少弱精子症的临床效果及其可行性与安全性。方法:120例少弱精子症患者随机分为他莫昔芬片口服治疗组(他莫昔芬组)、中频穴位电刺激治疗组(穴位电刺激组)与联合治疗组,每组40例。连续治疗8周,记录各组治疗前后的精液体积、精子总数及浓度、总活力、前向运动(PR)精子百分率及血清生殖激素(FSH、LH、T)水平,对比分析3组患者治疗前后的精液参数及生殖激素水平。结果:所有患者均完成本研究,治疗前后3组精液体积无明显改善(P0.05)。与治疗前对比,3组均可改善生殖激素(FSH、LH、T)水平(P0.05);他莫昔芬组可以显著提高精子总数[(42.65±5.78)×10~6vs(25.16±2.05)×10~6,P0.05]及精子浓度[24.31±2.59)×10~6/ml vs(12.15±2.51)×10~6/ml,P0.05],而精子总活力及PR精子百分率无明显改善[(22.61±5.75)%vs(21.78±8.81)%;(16.76±5.86)%vs(15.87±7.81)%,P均0.05];穴位电刺激组可以增加精子总活力率[(32.43±4.97)%vs(24.81±8.27)%,P0.05]及PR精子百分率[(27.17±5.09)%vs(19.71±9.15)%,P0.05],而精子总数及精子浓度无明显改善[(25.87±4.96)×10~6vs(23.23±3.14)×10~6;(14.12±2.47)×10~6/ml vs(11.27±2.24)×10~6/ml,P均0.05];联合治疗组不仅可以提高精子总数[(51.14±3.69)×10~6vs(26.17±5.05)×10~6,P0.05]及精子浓度[(27.28±1.98)×10~6/ml vs(12.78±2.41)×10~6/ml,P0.05],而且可以显著提高精子总活力[(37.12±5.33)%vs(23.89±9.05)%,P0.05]及PR精子百分率[(31.09±7.12)%vs(17.14±8.04)%,P0.05],并且显著优于他莫昔芬组和穴位电刺激组(P0.05)。联合治疗组总有效率(97.5%)显著高于他莫昔芬组(72.5%)和穴位电刺激组(75.0%),P0.05。结论:中频穴位电刺激联合他莫昔芬片口服可以明显改善特发性少弱精子症患者的精液质量和生殖激素水平,有一定的临床推广意义。
[Abstract]:Objective: to investigate the clinical efficacy and safety of middle frequency acupoint electric stimulation combined with tamoxifen tablets in the treatment of oligozoospermia. Methods 120 cases of oligoasthenospermia were randomly divided into three groups: tamoxifen oral treatment group (tamoxifen group), medium frequency acupoint stimulation group (Acupoint electric stimulation group) and combined treatment group (40 cases in each group). After 8 weeks of continuous treatment, semen volume, total sperm count and concentration, total motility, forward motility (PR) sperm percentage and serum reproductive hormone (FSH,LH,T) levels were recorded before and after treatment. Semen parameters and reproductive hormone levels were analyzed before and after treatment. Results: all the patients completed the study, the semen volume of the three groups did not improve significantly before and after treatment (P0.05). 涓庢不鐤楀墠瀵规瘮,3缁勫潎鍙敼鍠勭敓娈栨縺绱，
本文编号：2223824
[Abstract]:Objective: to investigate the clinical efficacy and safety of middle frequency acupoint electric stimulation combined with tamoxifen tablets in the treatment of oligozoospermia. Methods 120 cases of oligoasthenospermia were randomly divided into three groups: tamoxifen oral treatment group (tamoxifen group), medium frequency acupoint stimulation group (Acupoint electric stimulation group) and combined treatment group (40 cases in each group). After 8 weeks of continuous treatment, semen volume, total sperm count and concentration, total motility, forward motility (PR) sperm percentage and serum reproductive hormone (FSH,LH,T) levels were recorded before and after treatment. Semen parameters and reproductive hormone levels were analyzed before and after treatment. Results: all the patients completed the study, the semen volume of the three groups did not improve significantly before and after treatment (P0.05). 涓庢不鐤楀墠瀵规瘮,3缁勫潎鍙敼鍠勭敓娈栨縺绱，
本文编号：2223824
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