1562例经皮肾穿刺活检患者的临床及病理分析

发布时间：2018-09-17 18:14

【摘要】：目的分析因肾脏疾病行经皮肾穿刺活检患者的临床及病理分型。方法选取2006—2012年中国医科大学附属盛京医院肾脏内科住院行经皮肾穿刺活检的辽宁地区患者1 562例,回顾性分析患者的临床资料和病理资料。结果 1 562例经皮肾穿刺活检患者中,原发性肾小球疾病(PGN)1 222例(78.23%),继发性肾小球疾病(SGN)277例(17.73%),肾小管间质性疾病(TID)44例(2.82%),遗传性肾病11例(0.71%),未分类肾病8例(0.51%)。PGN中最常见的病理类型为Ig A肾病475例(38.87%),其次为膜性肾病311例(25.45%)、系膜增生性肾小球肾炎243例(19.89%);SGN中最常见的病理类型为过敏性紫癜性肾炎68例(24.55%),其次为狼疮性肾炎45例(16.25%)、糖尿病肾病44例(15.88%)。不同年龄患者肾脏病理检查结果构成比较,差异有统计学意义(P0.05);不同性别和年份患者肾脏病理检查结果构成比较,差异无统计学意义(P0.05)。肾穿刺指征分别为肾病综合征662例(42.38%),肾炎综合征448例(28.68%)、无症状性尿异常223例(14.28%)、急性肾功能不全105例(6.72%)、肉眼血尿59例(3.78%)、慢性肾功能不全53例(3.39%)、其他12例(0.77%)。不同性别患者肾穿刺指征比较,差异无统计学意义(P0.05);不同年龄和肾脏病理检查结果患者肾穿刺指征比较,差异有统计学意义(P0.05)。结论肾穿刺活检患者中,PGN最常见,其中Ig A肾病为最常见病理类型,其次为膜性肾病;SGN以过敏性紫癜性肾炎和狼疮性肾炎多见。PGN和SGN最常见肾穿刺指征为肾病综合征和肾炎综合征,同一种病理类型可以有不同的临床表现。
[Abstract]:Objective to analyze the clinical and pathological types of patients with renal diseases undergoing percutaneous renal biopsy. Methods from 2006 to 2012, 1 562 patients in Department of Renal Medicine of Shengjing Hospital affiliated to China Medical University were selected for percutaneous renal biopsy in Liaoning province. The clinical and pathological data of the patients were analyzed retrospectively. Results among 1 562 patients with percutaneous renal biopsy, Primary glomerular disease 1 222 cases (78.23%), secondary glomerular disease (SGN) 277 cases (17.73%), tubulointerstitial disease (TID) 44 cases (2.82%), hereditary nephropathy 11 cases (0.71%), unclassified nephropathy 8 cases (0.51%) .PGN: Ig A nephropathy 475 cases (38.87%) There were 311 cases (25.45%) of membranous nephropathy, 243 cases (19.89%) of Mesangial proliferative glomerulonephritis, 68 cases (24.55%) of Henoch-Schonlein purpura nephritis, 45 cases (16.25%) of lupus nephritis and 44 cases (15.88%) of diabetic nephropathy. The composition of renal pathological examination results of different age patients, the difference was statistically significant (P0.05); different sex and year of renal pathological examination results were compared, the difference was not statistically significant (P0.05). The renal puncture indications were nephrotic syndrome in 662 cases (42.38%), nephritis syndrome in 448 cases (28.68%), asymptomatic urinary abnormality in 223 cases (14.28%), acute renal insufficiency in 105 cases (6.72%), gross hematuria in 59 cases (3.78%), chronic renal insufficiency in 53 cases (3.39%), and other 12 cases (0.77%). There was no significant difference in renal puncture indication between different gender patients (P0.05), and there was significant difference in renal puncture indication between different age and renal pathological examination (P0.05). Conclusion Ig A nephropathy is the most common pathological type in renal biopsy patients. Secondly, the most common renal puncture indications of membranous nephropathy were allergic purpura nephritis and lupus nephritis. The most common renal puncture indications were nephrotic syndrome and glomerulonephritis syndrome, and the same pathological type could have different clinical manifestations.
【作者单位】：中国医科大学附属盛京医院肾内科;辽宁省人民医院肾内科;
【基金】：辽宁省科学技术计划项目(2013225049)
【分类号】：R692

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