X射线修复交叉互补基因3多态性与膀胱癌易感性的关系

发布时间：2018-10-12 11:50

【摘要】：目的探讨X射线修复交叉互补基因3(XRCC3)rs861539(CT)多态性与膀胱癌易感性的关系。方法用聚合酶链反应-限制性片段长度多态性方法检测201例膀胱癌患者(病例组)及200例年龄、性别相匹配的健康人(对照组)XRCC3 rs861539(CT)的基因型,比较各基因型与膀胱癌发病风险以及膀胱癌病理分期、分级的关系,同时分层分析其与吸烟的关系。结果病例组XRCC3 rs861539位点CC、CT、TT 3种基因型分布频率分别为85.6%、13.9%、0.5%,对照组分别为93%、6.5%、0.5%,两组基因型频率分布差异有统计学意义(P0.05)。与基因型CC相比,携带突变等位基因T的基因型(CT+TT)发生膀胱癌的风险增加3.077倍(OR 95%CI:1.452~6.882,P0.05);XRCC3 rs861539基因型在吸烟及膀胱癌病理分期、分级之间的分布差异无统计学意义(P均0.05)。结论 XRCC3 rs861539多态性可能增加膀胱癌的发病风险。
[Abstract]:Objective to investigate the relationship between X-ray repair cross-complementary gene 3 (XRCC3) rs861539 (CT) polymorphism and bladder cancer susceptibility. Methods XRCC3 rs861539 (CT) genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 201 bladder cancer patients (case group) and 200 age-matched healthy subjects (control group). The relationship between genotypes and the risk of bladder cancer, the pathological stage and grade of bladder cancer was compared, and the relationship between genotype and smoking was analyzed by stratification. Results the frequencies of CC,CT,TT genotypes at XRCC3 rs861539 locus in the case group were 85.6 and 13.9g, respectively, and those in the control group were 936.5g and 0.5g, respectively. There was significant difference in the frequency distribution between the two groups (P0.05). Compared with genotype CC, the risk of bladder cancer in genotype (CT TT) with mutant allele T was increased 3.077 times (OR 95 CI: 1.452C6.882p0.05), and the distribution of XRCC3 rs861539 genotype in smoking, pathological stage and grade of bladder cancer had no significant difference (P0.05). Conclusion XRCC3 rs861539 polymorphism may increase the risk of bladder cancer.
【作者单位】： 广西医科大学第一附属医院;广西医科大学附属肿瘤医院;
【基金】：广西壮族自治区教育厅科研资助项目(201012MS046)
【分类号】：R737.14
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本文编号：2266001