慢性肾脏病患者血清妊娠相关血浆蛋白A水平及其与颈动脉内中膜厚度的相关性

发布时间：2018-10-17 19:41

【摘要】：目的探讨慢性肾脏病(CKD)患者血清妊娠相关蛋白(PAPP)-A水平与颈动脉内中膜厚度(IMT)的相关性。方法选择CKD 3~5期患者71例,采用酶联免疫吸附(ELISA)法检测血清PAPP-A水平,多普勒超声测量颈动脉IMT及颈动脉斑块,根据颈动脉超声检测结果将CKD患者分为颈动脉正常组和颈动脉粥样硬化(AS)组,比较两组血清PAPP-A水平的变化;16例健康体检者作为对照组。结果 CKD患者血清PAPP-A水平较对照组明显升高(P0.01),且随着肾功能的恶化呈进行性升高。CKD伴颈AS组血清PAPP-A水平较颈动脉正常组明显升高(P0.01)。CKD患者颈动脉IMT与血清PAPP-A显著正相关(r=0.521,P0.001)。PAPP-A是IMT独立危险因素。结论 CKD患者血清PAPP-A与颈AS密切相关,血清PAPP-A可能参与了CKD患者AS的发生和发展。
[Abstract]:Objective to investigate the correlation between serum pregnancy-associated protein (PAPP) A) and carotid intima-media thickness (IMT) in patients with chronic kidney disease (CKD). Methods Serum PAPP-A levels were measured by enzyme linked immunosorbent assay (ELISA) and carotid IMT and carotid plaque were measured by Doppler ultrasound in 71 patients with stage 3 CKD. According to the results of carotid ultrasound, the patients with CKD were divided into normal carotid group and carotid atherosclerotic (AS) group to compare the changes of serum PAPP-A levels in the two groups, and 16 healthy people as control group. Results the serum PAPP-A level in CKD patients was significantly higher than that in the control group (P0.01), and the serum PAPP-A level in the CKD with carotid AS group was significantly higher than that in the normal carotid artery group (P0.01). CKD patients with carotid IMT and serum PAPP-A was significantly positive. PAPP-A was an independent risk factor for IMT. Conclusion Serum PAPP-A is closely related to cervical AS in patients with CKD, and serum PAPP-A may be involved in the occurrence and development of AS in CKD patients.
【作者单位】：河北医科大学第二医院肾内科;
【分类号】：R692

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