保肾片对造影剂肾病患者肾损伤因子的影响

发布时间：2018-10-24 17:10

【摘要】：目的通过检测肾小球滤过率(eG FR),血胱抑素(Cys)-C,尿N-乙酰-β-D-葡萄苷酶(NAG),尿β-半乳糖苷酶(GAL)研究保肾片对造影剂肾病的预防和治疗作用。方法将接受冠脉造影术及经皮冠脉介入术(PCI)的患者80例随机分为两组,治疗组:常规标准治疗的基础上加保肾片(40例);对照组:常规标准治疗(40例)。所有患者检测术前24 h、术后24 h及72 h血肌酐、血Cys-C、尿NAG、尿GAL水平。结果 (1)术后24 h治疗组Cys-C较对照组低(P0.05);术后72 h治疗组血肌酐、血Cys-C、尿NAG、尿GAL较对照组明显降低(P0.01),治疗组eG FR较对照组高(P0.01)。(2)治疗组术后72 h尿NAG、尿GAL较术前降低(P0.05),血肌酐较术前明显降低(P0.01),eG FR较术前升高(P0.01);术后24 h较术前无明显差异(P0.05);(3)对照组血Cys-C术后24 h升高(P0.05);术后72 h尿NAG较术前升高(P0.05),血肌酐、尿GAL、血Cys-C较术前明显升高(P0.01),eG FR较术前明显降低(P0.01)。(4)术后72 h,治疗组造影剂肾病5例,对照组造影剂肾病40例,两组差异显著(P0.05)。结论保肾片可能通过改善eG FR、Cys-C、尿NAG、尿GAL等肾损伤因子的表达对造影剂肾病产生防治作用。
[Abstract]:Objective to study the preventive and therapeutic effects of Baoshen tablets on contrast nephropathy by detecting glomerular filtration rate (eG FR),) blood cystatin (Cys) C and urine N acetyl 尾 D glucosidase (NAG), urine 尾 galactosidase (GAL). Methods Eighty patients with (PCI) underwent coronary angiography and percutaneous coronary intervention were randomly divided into two groups: the treatment group (n = 40), the control group (n = 40), the routine standard treatment group (n = 40) and the control group (n = 40). Serum creatinine was measured 24 hours before operation, 24 hours after operation and 72 hours after operation. Urine GAL levels of Cys-C, and urine NAG, were measured in all patients. Results (1) the Cys-C of the treatment group was lower than that of the control group at 24 hours after operation (P0.05), and the serum creatinine of the treatment group at 72 hours after operation was lower than that of the control group. The urinary GAL of serum Cys-C, urine NAG, was significantly lower than that of the control group (P0.01), the eG FR of the treatment group was higher than that of the control group (P0.01). (2), the urine NAG, urine GAL of the treatment group was significantly lower than that of the pre-operation (P0.05), the serum creatinine was significantly lower than the preoperative (P0.01), eG FR), and 24 hours after the operation was not clear (P0.01). The significant difference (P0.05); (3) was found between the control group and the control group (P0.05) at 24 hours after the operation, and at 72 hours after the operation, the urinary NAG was significantly higher than that before the operation (P0.05), and the serum creatinine was also increased. The level of Cys-C in urine GAL, was significantly higher than that before operation (P0.01), eG FR decreased significantly 72 hours after operation (P0.01). (4). Contrast agent nephropathy in 5 cases in the treatment group and contrast agent nephropathy in 40 cases in the control group, the difference between the two groups was significant (P0.05). Conclusion Baoshen tablet may play a preventive and therapeutic role in contrast nephropathy by improving the expression of renal injury factors such as NAG, urine and GAL in eG FR,Cys-C, urine.
【作者单位】：南京中医药大学附属医院江苏省中医院;
【基金】：南京市科技委计划重点项目(201503012)
【分类号】：R692

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