肾炎康复片联合贝那普利治疗早期糖尿病肾病的临床研究

发布时间：2018-10-31 11:32

【摘要】：目的:探讨肾炎康复片联合贝那普利治疗早期糖尿病肾病(DN)的临床疗效。方法:选择DN患者120例随机分为观察组(n=60)与对照组(n=60),对照组给予贝那普利治疗,观察组给予贝那普利联合肾炎康复片治疗,对比两组患者临床疗效、治疗前后及治疗后24 h尿蛋白定量(Upr)、血清肌酐(Scr)、尿素氮(BUN)、空腹血糖(FPG)变化以及不良反应。结果:观察组患者治疗总有效率为91.7%,显著高于对照组的66.7%(P0.01);两组患者治疗后24 h Upr、Scr、BUN、FPG均显著低于治疗前(P0.05),且治疗后观察组显著低于对照组(P0.05)。两组患者不良反应发生率比较无统计学差异(P0.05)。结论:肾炎康复片联合贝那普利治疗DN具有显著疗效,安全性高,可减少患者尿蛋白排出,改善肾脏功能,调节机体免疫功能。
[Abstract]:Objective: to investigate the clinical effect of nephritis rehabilitation tablet combined with benazepril in the treatment of early diabetic nephropathy (DN). Methods: one hundred and twenty patients with DN were randomly divided into two groups: the observation group (n = 60) and the control group (n = 60). The control group was treated with benazepril, the observation group was treated with benazepril combined with nephritis rehabilitation tablet, and the clinical efficacy was compared between the two groups. Serum creatinine, (Scr), urea nitrogen, (BUN), fasting blood glucose, (FPG) and adverse reactions were measured before and 24 hours after treatment. Results: the total effective rate of treatment in the observation group was 91.7%, which was significantly higher than that in the control group (66.7%) (P0.01). The Upr,Scr,BUN,FPG of the two groups was significantly lower than that of the control group 24 hours after treatment (P0.05), and that of the observation group was significantly lower than that of the control group (P0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P0.05). Conclusion: the combination of nephritis and benazepril is effective and safe in the treatment of DN. It can reduce urinary protein excretion, improve renal function and regulate immune function.
【作者单位】：北京大学第一医院中西医结合科;
【分类号】：R587.2;R692.9

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