中药、中西药联合与西药治疗男性少弱精子症疗效比较的系统评价

发布时间：2018-11-24 12:52

【摘要】：目的：系统分析中药、中西药联合治疗男性少弱精子症的疗效,以期对中药、中西药联合治疗男性少弱精子症的疗效做出客观、可信的评价,为男性少弱精子症的临床治疗用药治疗提供有价值的参考。方法：采用循证医学的方法,全面检索国内2007年至2013年12月中医药治疗男性少弱精子症的临床研究文献,按照文献可靠性分级、Jadad量表等评价文献的质量,对符合纳入标准的文献进行系统评价,部分文献进行Meta-分析。评因为各文献侧重评价指标不尽相同,所以系统评价指标包括有效率、精子密度、活动率等。其中所有的二分变量资料本系统评价均以相同方式来评价,即以比数比(OR)、相对危险度(RR)来评价；所有的连续变量资料则以另一种方式来评价,均以加权均数差(WMD)来评价。总体异质性卡方检验p0.05采用固定效应模型分析,反之采用随机效应模型分析。结果：截止至2013年12月,符合检索条件全部纳入标准的文献总共是有18篇,共2551例病人。本系统评价显示,中药、中西药联合对男性少弱精子症的治疗与西药相比,在提高临床有效率方面有明显的优势,同时数据也明确表示出了药物不良反应的发生的概率也相对比较低。由于实验侧重点不同,男性激素水平方面的数据极少涉及。但是,由于各种误差的存在,尚不能完全排除例如发表偏倚等相关因素对结果的影响。结论：中药、中西药联合对男性少弱精子症的治疗与西药相比,有更好的临床疗效,同时不良反应的发生率也较低。但是,由于各种误差的存在,尚不能完全排除例如发表偏倚等相关因素对结果的影响。这些因素无可避免的引起了这篇系统评价在临床价值方面略微降低。
[Abstract]:Objective: to analyze the efficacy of Chinese medicine and western medicine in the treatment of male oligozoospermia, in order to make an objective and credible evaluation on the efficacy of Chinese medicine and western medicine in the treatment of male oligozoospermia. To provide a valuable reference for the treatment of male oligozoospermia. Methods: Evidence-based medicine (EBM) was used to search the literature on the treatment of oligozoospermia in China from 2007 to December 2013. The quality of the literature was evaluated according to the reliability classification and Jadad scale. A systematic review of the literature that meets the inclusion criteria is carried out, and some of the documents are analyzed by Meta-. Because the evaluation indexes are not the same, the systematic evaluation indexes include efficiency, sperm density, motility rate and so on. All the binary variables were evaluated in the same way, that is, the relative risk of (OR), was evaluated by (RR). All the data of continuous variables are evaluated in another way, which is evaluated by weighted mean difference (WMD). The global heterogeneity chi-square test p0.05 uses fixed effect model analysis, whereas uses random effect model analysis. Results: as of December 2013, there were 18 articles (2551 patients) that met the criteria for retrieval. The systematic evaluation shows that the treatment of male oligozoospermia with traditional Chinese medicine and western medicine has obvious advantages in improving the clinical effective rate compared with western medicine. The data also show that the probability of adverse drug reactions is relatively low. Data on male hormone levels are rarely available because of the different focus of the experiment. However, due to the existence of various errors, the influence of related factors, such as publication bias, on the results cannot be completely excluded. Conclusion: the treatment of oligozoospermia with traditional Chinese medicine and western medicine is better than that of western medicine, and the incidence of adverse reactions is lower. However, due to the existence of various errors, the influence of related factors, such as publication bias, on the results cannot be completely excluded. These factors inevitably led to a slight decline in the clinical value of this systematic review.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R698.2

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