中医清热利湿法联合西药治疗IgA肾病的Meta分析

发布时间：2018-12-11 21:36

【摘要】：目的系统评价中医清热利湿法联合西药治疗IgA肾病的疗效。方法计算机检索CBM、CNKI、VIP、Pubmed等数据库,搜集中医清热利湿法联合西药(试验组)与单纯西药(对照组)治疗IgA肾病的随机对照试验,并手工检索相关会议论文,检索时限均从建库至2015年12月。由2位评价者根据纳入和排除标准独立筛选文献、提取资料并进行文献质量评价,然后采用Rev Man 5.3软件进行Meta分析。结果共纳入6个研究,Meta分析结果显示:中医清热利湿法联合西药在降低尿蛋白[MD=—0.35,95%CI(—0.46,—0.24),P0.00001]、尿红细胞计数[MD=—3.94,95%CI(—5.32,—2.55),P0.00001]方面优于单纯西药治疗,且治疗总有效率[RR=1.96,95%CI(1.62,2.25),P0.00001]也高于单纯西药治疗。但在改善肾功能[MD=—12.34,95%CI(—38.13,13.44),P=0.35]方面,两组差异无统计学意义。结论当前证据显示,中医清热利湿法联合西药可减少IgA肾病患者蛋白尿、血尿,并能提高疗效,但受纳入研究的数量及质量所限,上述结论尚需更多高质量的相关研究加以验证。
[Abstract]:Objective to evaluate the efficacy of traditional Chinese medicine (TCM) combined with western medicine in treating IgA nephropathy. Methods CBM,CNKI,VIP,Pubmed and other databases were searched by computer to collect the randomized controlled trials of traditional Chinese medicine combined with western medicine (experimental group) and western medicine (control group) in the treatment of IgA nephropathy, and the related conference papers were searched manually. The time limit for retrieval is from the construction of the database to December 2015. According to the inclusion and exclusion criteria, two evaluators independently sifted the literature, extracted the data and evaluated the quality of the literature. Then the Meta analysis was carried out with Rev Man 5.3 software. Results the results of Meta analysis showed that Chinese medicine combined with western medicine could reduce urinary protein [MD=-0.35,95%CI (-0.46U -0.24), P 0.00001]. The urine erythrocyte count [MD=-3.94,95%CI (-5.32 ~ 2.55), P 0.00001] was better than that of western medicine alone, and the total effective rate [RR=1.96,95%CI (1.62 卤2.25), P 0.00001] was higher than that of western medicine alone. However, there was no significant difference between the two groups in improving renal function [MD=-12.34,95%CI (-38.13 ~ 13.44), P _ (0.35)]. Conclusion the current evidence shows that the combination of traditional Chinese medicine and western medicine can reduce proteinuria and hematuria in patients with IgA nephropathy, and improve the curative effect, but it is limited by the quantity and quality of the study. These conclusions need to be verified by more high-quality related studies.
【作者单位】：内蒙古医科大学中医学院;中国中医科学院广安门医院;
【基金】：内蒙古自治区自然基金面上项目(No.2015MS0826) 内蒙古医科大学青年创新基金项目(No.YKD2014QNCX019)
【分类号】：R692.3

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