盐酸坦索罗辛对输尿管结石患者尿微量蛋白及N-乙酰-β-D-葡萄糖苷酶含量的影响

发布时间：2018-12-22 09:23

【摘要】：目的探讨盐酸坦索罗辛对输尿管结石患者尿微量蛋白及N-乙酰-β-D-葡萄糖苷酶(NAG)含量的影响。方法输尿管结石患者101例,随机分为实验组51例和对照组50例。两组均给予抗感染及解痉止痛对症治疗。实验组在此基础上给予盐酸坦索罗辛,对照组给予安慰剂。分别于治疗前后测定实验组和对照组尿微量蛋白及NAG含量、血尿素氮、肌酐、转氨酶含量,记录肾绞痛发生次数,自然排石时间以及解痉止痛药的使用剂量。结果治疗后与对照组比较,实验组尿微量蛋白及NAG含量较低(P0.05);自然排石时间明显缩短(P0.05),肾绞痛发生次数减少(P0.05),解痉止痛药剂量降低(P0.05)。结论盐酸坦索罗辛能有效降低输尿管结石患者尿微量蛋白及NAG含量,减少肾绞痛发生次数,减少解痉止痛药使用剂量,缩短自然排石时间,且对肝肾功能没有影响。
[Abstract]:Objective to investigate the effect of tamsoloxine hydrochloride on urinary microprotein and (NAG) content of N-acetyl- 尾 -D-glucosidase in ureteral calculi. Methods 101 patients with ureteral calculi were randomly divided into experimental group (51 cases) and control group (50 cases). Both groups were given anti-infection and antispasmodic treatment. The experimental group was given tamsoloxine hydrochloride and the control group was given placebo. The contents of urinary trace protein and NAG, blood urea nitrogen, creatinine and transaminase were measured before and after treatment. The occurrence times of renal colic, the time of natural lithotomy and the dosage of antispasmodic painkillers were recorded. Results compared with the control group, the contents of urinary trace protein and NAG in the experimental group were lower than those in the control group (P0.05). The time of natural lithotomy was significantly shortened (P0.05), the frequency of occurrence of renal colic was decreased (P0.05), and the dosage of antispasmodic drugs was decreased (P0.05). Conclusion Tansoloxine hydrochloride can effectively reduce the contents of urinary trace protein and NAG in ureteral calculi, reduce the frequency of renal colic, reduce the dosage of antispasmodic painkillers, shorten the time of natural lithotomy, and have no effect on the function of liver and kidney.
【作者单位】：遵义医学院附属医院泌尿外科;
【基金】：贵州省科学技术基金(黔科合LH字〔2014〕7551号)
【分类号】：R693.4

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