阿托伐他汀与辅酶Q10联合应用对老年2型糖尿病肾病的影响

发布时间：2018-12-27 13:03

【摘要】：目的探讨阿托伐他汀与辅酶Q10联合应用对老年2型糖尿病肾病患者相关指标的影响。方法 65例老年2型糖尿病患者按照随机自愿的原则分为他汀组和联合组。连续治疗12 w后,检测干预前后的糖化血红蛋白(Hb A1c)、空腹血糖(FPG)、血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血清胱抑素C(Cys C)、尿β2微球蛋白(β2-MG)以及治疗后两组的总辅酶Q10、超氧化物歧化酶(SOD)、丙二醛(MDA)活性。结果治疗前后比较,两组患者TC、TG、LDL-C、Cys C、β2-MG显著下降,HDL-C均显著升高(P0.05),联合组患者Hb A1c、FPG显著下降(P0.05),他汀组无显著差别。治疗前后比较,联合组Hb A1c、FPG、TC、TG、LDL-C、β2-MG优于他汀组(P0.05)。给药后与联合组比较,他汀组总辅酶Q10、SOD均显著下降,MDA均显著升高(P0.05)。结论阿托伐他汀与辅酶Q10联合应用比阿托伐他汀单独使用对老年2型糖尿病肾病患者更加有效,其机制可能与抗氧化有关。
[Abstract]:Objective to investigate the effect of Atto vastatin combined with coenzyme Q 10 on the related indexes in elderly patients with type 2 diabetic nephropathy. Methods Sixty-five elderly patients with type 2 diabetes were randomly divided into two groups: statin group and combined group. After 12 weeks of continuous treatment, glycosylated hemoglobin (Hb A1c), fasting blood glucose (FPG), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) were measured before and after intervention. High density lipoprotein cholesterol (HDL-C), serum cystatin C (Cys C), urine 尾 2 microglobulin (尾 2-MG), total coenzyme Q10 and (SOD), malondialdehyde (MDA) activity of the two groups after treatment. Results before and after treatment, TC,TG,LDL-C,Cys C, 尾 2-MG decreased significantly and HDL-C increased significantly in both groups (P0.05), and Hb A1cFPG decreased significantly in combination group (P0.05), but there was no significant difference in statin group. Before and after treatment, Hb A _ 1C _ (1) C _ (1) T _ (1) T 2-MG and 尾 2-MG in the combined group were better than those in the statin group (P 0.05). Compared with the combined group, the total coenzyme Q10 SOD decreased significantly and the MDA increased significantly in the statins group (P0.05). Conclusion the combination of Atto vastatin and coenzyme Q10 is more effective than Atto vastatin alone in elderly patients with type 2 diabetic nephropathy, and its mechanism may be related to antioxidation.
【作者单位】：遵义市第一人民医院内分泌科;
【分类号】：R587.2;R692.9

【相似文献】