PKRP联合内分泌治疗对晚期前列腺癌伴BOO的临床观察

发布时间：2019-02-09 20:27

【摘要】：目的：观察经尿道前列腺双极等离子电切术(PKRP)联合内分泌治疗对晚期前列腺癌伴膀胱出口梗阻(B00)的临床疗效。方法：收集2012年2月至2014年1月昆明医科大学第二附属医院47例伴膀胱出口梗阻且行经尿道前列腺双极等离子电切术联合内分泌治疗的晚期前列腺癌患者的临床资料,记录并通过统计学分析其治疗前后国际前列腺症状评分(IPSS)、生活质量评分(QOL)、残余尿量(RU)、最大尿流率(Qmax)、血清前列腺特异性抗原(PSA)等指标的变化程度和趋势。结果：所有患者手术顺利,并发症少,术后所有患者排尿困难的症状均明显改善,2例出现暂时性尿失禁,其余未见明显尿失禁。8例骨痛患者骨痛明显缓解,19例核素骨扫描示骨转移灶明显缩小,3例患者骨转移灶消失。IPSS评分、Qmax、 QOL、RU较术前明显改善,PSA较术前明显下降。结论：经尿道前列腺双极等离子电切术联合内分泌治疗能明显提高伴膀胱出口梗阻的晚期前列腺癌患者的生活质量,能显著缓解膀胱出口梗阻症状,可作为晚期前列腺癌伴膀胱出口梗阻的患者的一种重要治疗方法。
[Abstract]:Objective: to observe the clinical effect of transurethral bipolar plasma resection (PKRP) combined with endocrine therapy for advanced prostate cancer with bladder outlet obstruction (B00). Methods: from February 2012 to January 2014, the clinical data of 47 patients with advanced prostate cancer with bladder outlet obstruction treated by transurethral bipolar plasma resection combined with endocrine therapy in the second affiliated Hospital of Kunming Medical University were collected. The international prostatic symptom score (IPSS),) before and after treatment was recorded and analyzed statistically. (IPSS), quality of life score (QOL),) residual urine volume (RU),) maximum urinary flow rate (Qmax),) was recorded and analyzed before and after treatment. The change degree and trend of serum prostate specific antigen (PSA). Results: all the patients had smooth operation and few complications. The symptoms of dysuria were improved significantly in all patients after operation. Temporary urinary incontinence was found in 2 patients, and no obvious urinary incontinence was seen in the rest. Bone scan of 19 patients showed that bone metastases decreased significantly, and bone metastases disappeared in 3 patients. IPSS score, Qmax, QOL,RU and PSA were significantly improved compared with those before operation. Conclusion: transurethral bipolar plasma resection combined with endocrine therapy can significantly improve the quality of life of patients with advanced prostate cancer with bladder outlet obstruction, and can significantly alleviate the symptoms of bladder outlet obstruction. It can be used as an important treatment for advanced prostate cancer with bladder outlet obstruction.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.25

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