FSHR基因Thr307Ala和Asn680Ser位点多态性与男性不育关系的Meta分析

发布时间：2019-02-18 12:56

【摘要】：目的:用Meta分析的方法综合评价FSHR Thr307Ala-Asn680Ser等位基因多态性与男性不育的关联性。方法:检索Pub Med、EMBASE、Web of Science、中国知网和万方等中英文数据库2005至今文献,依据选择标准收集相关病例对照研究数据,应用Stata 11.0软件对符合条件的研究结果进行Meta分析。结果:符合纳入标准的共12篇文献,包含病例组2 893例和对照组3 312例。经综合分析:在3种比较模型(纯合比较模型、杂合比较模型和显性比较模型)中,Thr307Ala(rs6165)位点多态性是男性不育的危险因素,OR值分别为1.26(95%CI:1.03~1.54),P=0.023;1.18(95%CI:1.03~1.36),P=0.018;1.20(95%CI:1.05~1.37),P=0.006)。而Asn680Ser(rs6166)位点多态性在两种比较模型(纯合比较模型和隐性比较模型),是男性不育的危险因素,OR值分别为1.24(95%CI:1.05~1.45),P=0.009;1.20(95%CI=1.04~1.39),P=0.013。分层Meta分析结果则表明,在纯合比较模型中,Thr307Ala和Asn680Ser位点多态性在白种人群中是男性不育的危险因素,OR值分别为1.37(95%CI:1.03~1.82),P=0.003;1.21(95%CI:1.00~1.47),P=0.048。结论:在纯合比较模型中,FSHR Thr307Ala和Asn680Ser位点多态性可能是男性不育发生的影响因素之一。
[Abstract]:Objective: to evaluate the association between FSHR Thr307Ala-Asn680Ser allelic polymorphism and male infertility by Meta analysis. Methods: 2005 documents of Chinese and English databases such as Pub Med,EMBASE,Web of Science, and Wanfang were searched, and relevant case-control study data were collected according to the selection criteria, and the results were analyzed by Meta with Stata 11.0 software. Results: there were 12 articles including 2 893 cases in the case group and 3 312 cases in the control group. Comprehensive analysis showed that Thr307Ala (rs6165) polymorphism was the risk factor of male infertility in three comparison models (homozygous comparison model, heterozygosity comparison model and dominant comparison model), and the OR value was 1.26 (95%CI:1.03~1.54), respectively. P0. 023; 1.18 (95%CI:1.03~1.36), 0.018 (95%CI:1.05~1.37), P0. 006). Asn680Ser (rs6166) polymorphism was a risk factor for male infertility in two comparison models (homozygous comparison model and recessive comparison model). The OR values were 1.24 (95%CI:1.05~1.45) and 0.009, respectively. 1. 20 (95%CI=1.04~1.39), P0. 013. Stratified Meta analysis showed that in homozygous comparison model, Thr307Ala and Asn680Ser polymorphism were the risk factors of male infertility in white population. The OR values were 1.37 (95%CI:1.03~1.82) and 0.003, respectively. 1. 21 (95%CI:1.00~1.47), P0. 048. Conclusion: in homozygous comparison model, FSHR Thr307Ala and Asn680Ser polymorphism may be one of the influencing factors of male infertility.
【作者单位】：江苏卫生健康职业学院中心实验室;江苏省省级机关医院检验科;南京医科大学附属第二医院检验科;南京军区南京总医院解放军临床检验医学研究所;
【分类号】：R698.2

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