黄芪当归合剂对肾病综合征患者肾功能、炎症机制及疗效的影响

发布时间：2019-03-27 16:57

【摘要】：目的:探讨黄芪当归合剂对肾病综合征患者肾功能、炎症机制及疗效的影响研究。方法:肾病综合征患者115例,依据随机数字表法随机分为观察组58例与对照组57例。对照组采用常规治疗,观察组在对照组基础上结合黄芪当归合剂治疗。两组疗程均为6个月。比较两组治疗前后肾功能指标、炎症因子水平变化,治疗疗效及药物不良反应发生情况。结果:两组Scr、BUN、24h尿蛋白定量、白蛋白治疗后明显降低(P0.05);观察组Scr、BUN、24h尿蛋白定量、白蛋白治疗后低于对照组(P0.05);两组IL-1、TNF-α、IL-6水平治疗后明显降低(P0.05);观察组IL-1、TNF-α、IL-6水平治疗后低于对照组(P0.05);观察组总有效率(93.10%)高于对照组(75.44%)(P0.05);两组均未见严重不良反应。结论:黄芪当归合剂可明显改善患者肾功能,减轻患者微炎症状态,且疗效显著,安全可靠,值得研究。
[Abstract]:Objective: to investigate the effect of Huangqi Danggui mixture on renal function, inflammatory mechanism and therapeutic effect in patients with nephrotic syndrome. Methods: 115 patients with nephrotic syndrome were randomly divided into observation group (58 cases) and control group (57 cases). The control group was treated with routine therapy, and the observation group was treated with Huangqi Danggui mixture on the basis of the control group. The course of treatment in both groups was 6 months. Renal function indexes, inflammatory factor levels, therapeutic efficacy and adverse drug reactions were compared between the two groups before and after treatment. Results: the urinary protein quantity of Scr,BUN,24h in the two groups was significantly lower than that in the control group after albumin treatment (P0.05), while the urinary protein quantity in the observation group was lower than that in the control group after albumin treatment (P0.05). The levels of IL-1,TNF- 伪 and IL-6 in the two groups decreased significantly after treatment (P0.05), and the levels of IL-1,TNF- 伪 and IL-6 in the observation group after treatment were lower than those in the control group (P0.05). The total effective rate of the observation group (93.10%) was higher than that of the control group (75.44%) (P0.05), and there was no serious adverse reaction between the two groups. Conclusion: Huangqi Danggui mixture can obviously improve the renal function and alleviate the microinflammatory state of the patients, and the curative effect is remarkable, and it is safe and reliable, which is worthy of study.
【作者单位】：缙云县中医院;
【分类号】：R692

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