肾移植后肾间质纤维化和肾小管萎缩研究进展
发布时间：2019-03-28 16:54
【摘要】：正慢性移植肾肾病(CAN)被认为是导致移植肾晚期功能丧失(失功)的主要原因,但由于其没有特异性的临床表现和组织学特征,不能充分有效地阐明疾病潜在的发展过程,间质纤维化和肾小管萎缩坏死(IF/TA)不能完全代替CAN,但其有具体性的移植肾失功的组织形态学改变特征,便于研究移植肾晚期失功的形成原因,本文就移植术后的IF/TA发病机制、诊断及治疗进行综述,并介绍其相关的研究进展。
[Abstract]:Chronic and orthotopic renal allograft nephropathy (CAN) is considered to be the main cause of late renal allograft failure. However, due to its lack of specific clinical and histological features, it is not able to fully and effectively clarify the potential development process of the disease. Interstitial fibrosis and tubular atrophy and necrosis (IF/TA) can not completely replace CAN, but it has specific morphological features of renal allograft failure, which facilitates the study of the causes of late renal allograft failure. In this paper, the pathogenesis, diagnosis and treatment of IF/TA after transplantation are reviewed, and the related research progress is introduced.
【作者单位】： 宁波大学附属泌尿肾病医院;
【基金】：宁波市自然科学基金(No.2009A610115,2009A610143)
【分类号】：R699.2
[Abstract]:Chronic and orthotopic renal allograft nephropathy (CAN) is considered to be the main cause of late renal allograft failure. However, due to its lack of specific clinical and histological features, it is not able to fully and effectively clarify the potential development process of the disease. Interstitial fibrosis and tubular atrophy and necrosis (IF/TA) can not completely replace CAN, but it has specific morphological features of renal allograft failure, which facilitates the study of the causes of late renal allograft failure. In this paper, the pathogenesis, diagnosis and treatment of IF/TA after transplantation are reviewed, and the related research progress is introduced.
【作者单位】： 宁波大学附属泌尿肾病医院;
【基金】：宁波市自然科学基金(No.2009A610115,2009A610143)
【分类号】：R699.2
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