肾移植受者血清可溶性HLA-G和可溶性CD30的水平与移植术后时间相关
发布时间：2019-04-02 17:47
【摘要】：目的研究肾移植受者术后不同时间血清可溶性人类白细胞抗原G(s HLA-G)和可溶性CD30(s CD30)的水平变化,探讨血清s HLA-G和s CD30的表达与肾移植术后时间的关系。方法选取11例肾移植受者,并募集10例健康供者作为对照组,分别检测术前及肾移植术后1年内s HLA-G和s CD30水平的动态变化;选取33例移植肾功能正常受者,按照移植术后时间分为术后≤5年组、5年术后时间≤10年组、术后10年组,观察血清s HLA-G和s CD30在术后1年以上的水平。结果肾移植受者术前血清s HLA-G水平与对照组、术后1周、术后1月的水平相当;术后3月血清s HLA-G水平高于术后1月;术后3、6、12月三组之间s HLA-G水平无显著变化;术后10年组显著高于术后≤5年组。血清s HLA-G水平与肾移植术后时间显著相关。术前s CD30水平高于正常对照组,术后1周较术前降低,术后1月较术后1周降低。术后1、3、6、12月之间及术后≤5年组、5年术后时间≤10年组、术后10年组之间s CD30水平无明显变化。s CD30水平仅与肾移植术后1月内时间显著相关。结论移植肾功能正常受者血清s HLA-G水平随着肾移植术后时间的延长而升高,而血清s CD30水平在肾移植术后1月内随时间延长而降低。
[Abstract]:Aim to study the changes of serum soluble human leukocyte antigen (G (s HLA-G) and soluble CD30 (s CD30) levels in renal transplant recipients at different time points, and to explore the relationship between the expression of serum s HLA-G and s CD30 and the time after renal transplantation. Methods 11 renal transplant recipients and 10 healthy donors were recruited as control group. The dynamic changes of s-HLA-G and s-CD30 levels were measured before and 1 year after renal transplantation. 33 recipients with normal renal function were divided into three groups according to the time after transplantation: 鈮，
本文编号：2452766
[Abstract]:Aim to study the changes of serum soluble human leukocyte antigen (G (s HLA-G) and soluble CD30 (s CD30) levels in renal transplant recipients at different time points, and to explore the relationship between the expression of serum s HLA-G and s CD30 and the time after renal transplantation. Methods 11 renal transplant recipients and 10 healthy donors were recruited as control group. The dynamic changes of s-HLA-G and s-CD30 levels were measured before and 1 year after renal transplantation. 33 recipients with normal renal function were divided into three groups according to the time after transplantation: 鈮，
本文编号：2452766
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