糖尿病肾病与贫血的相关性研究
发布时间：2019-05-23 03:41
【摘要】：目的：糖尿病肾病(Diabetic nephropathy, DN)是糖尿病(Diabetes mellitus, DM)的常见并发症之一,同时也是临床中导致终末期肾脏疾病的常见原因;而贫血是慢性肾脏病(chronic kidney disease, CKD)的常见并发症,我们常称之为肾性贫血(Renal Anemia, RA),发病率高,对CKD患者的工作,生活等诸多方面均可造成严重的影响,甚至可能加快CKD肾功能恶化的进展。本研究回顾性的分析总结贫血与2型糖尿病肾病的相关联系。 方法：选取2013年6月至2013年12月在兰州大学第二医院住院的2型糖尿病肾病患者60例做为研究组,其中男性32例,女性28例,收治年龄47—68岁,平均年龄(59.1±7.2岁),糖尿病病程4—-20年不等,平均病程(11.3年)。同期选取本院收住的无肾功能受损的2型糖尿病患者60例做为对照组,收集患者个人资料,测定空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbAlC)、尿微量白蛋白,C肽、TC、TG, HDL,LDL、C反应蛋白(CRP),24h尿白蛋白,以及血型,红细胞(RBC),血红蛋白(HGB),尿素(BUN),肌酐(CREA)测定,并测定患者肾小球滤过率(GFR)。贫血严重患者进一步行贫血三项,凝血酶原时间(PT),活化部分凝血活酶时间(APTT), D-2聚体(Dimer)等相关测定。对比分析两组间贫血的发生率,并进一步将糖尿病肾病合并贫血组患者的HbAlC, FPG与无合并贫血组患者的HbAlC, FPG进行对比,探讨贫血对HbAlC测定的影响以及对临床的指导意义。 结果：1.与无肾功能受损的2型糖尿病对照组相比较,糖尿病肾病组患者更容易合并发生贫血,差异有统计学意义(P0.05)。 2.糖尿病肾病患者合并贫血后,其糖化血红蛋白(HbAlc)的测定值低于无贫血患者组,说明HbAlc的测定受贫血的影响。 结论：在2型糖尿病肾病患者人群中,合并贫血的患病率显著高于非糖尿病肾病患者。并且当患者合并贫血后,糖化血红蛋白(HbAlc)的测定值不能真实反映患者的血糖水平,不能作为病情观察和疗效的监测指标。而贫血的发生会进一步加重CKD的恶化进展,严重影响糖尿病患者的生活质量,因此,需对此类患者尽早行相关检查,做到及时诊断和治疗。
[Abstract]:Objective: diabetic nephropathy (Diabetic nephropathy, DN) is one of the common complications of diabetic (Diabetes mellitus, DM), and it is also a common cause of end-stage renal disease in clinic. Anemia is a common complication of chronic kidney disease (chronic kidney disease, CKD). We often call it renal anemia with a high incidence of (Renal Anemia, RA), which can have a serious impact on the work, life and other aspects of CKD patients. It may even accelerate the deterioration of renal function in CKD. This study reviewed the relationship between anemia and type 2 diabetic nephropathy. Methods: from June 2013 to December 2013, 60 patients with type 2 diabetic nephropathy hospitalized in the second Hospital of Lanzhou University were selected as the study group, including 32 males and 28 females, with an average age of 59.1 卤7.2 years. The course of diabetes varied from 4 to 20 years, with an average course of disease (11.3 years). At the same time, 60 patients with type 2 diabetes mellitus without renal function impairment were selected as the control group. The personal data of the patients were collected, and the fasting blood glucose (FPG), postmeal blood glucose (2hPG) and glycosylated hemoglobin (HbAlC), urine microalbumin were measured. C peptide, TC,TG, HDL,LDL,C reactive protein (CRP), 24 h urinary albumin, blood group, red blood cell (RBC), hemoglobin (HGB), urea (BUN), creatine (CREA), and glomerular filtration rate (GFR). Were measured. Patients with severe anemia were further measured by three items of anemia and prothrombin time (PT), activated partial thromboplastin time (APTT), D 鈮，
本文编号：2483566
[Abstract]:Objective: diabetic nephropathy (Diabetic nephropathy, DN) is one of the common complications of diabetic (Diabetes mellitus, DM), and it is also a common cause of end-stage renal disease in clinic. Anemia is a common complication of chronic kidney disease (chronic kidney disease, CKD). We often call it renal anemia with a high incidence of (Renal Anemia, RA), which can have a serious impact on the work, life and other aspects of CKD patients. It may even accelerate the deterioration of renal function in CKD. This study reviewed the relationship between anemia and type 2 diabetic nephropathy. Methods: from June 2013 to December 2013, 60 patients with type 2 diabetic nephropathy hospitalized in the second Hospital of Lanzhou University were selected as the study group, including 32 males and 28 females, with an average age of 59.1 卤7.2 years. The course of diabetes varied from 4 to 20 years, with an average course of disease (11.3 years). At the same time, 60 patients with type 2 diabetes mellitus without renal function impairment were selected as the control group. The personal data of the patients were collected, and the fasting blood glucose (FPG), postmeal blood glucose (2hPG) and glycosylated hemoglobin (HbAlC), urine microalbumin were measured. C peptide, TC,TG, HDL,LDL,C reactive protein (CRP), 24 h urinary albumin, blood group, red blood cell (RBC), hemoglobin (HGB), urea (BUN), creatine (CREA), and glomerular filtration rate (GFR). Were measured. Patients with severe anemia were further measured by three items of anemia and prothrombin time (PT), activated partial thromboplastin time (APTT), D 鈮，
本文编号：2483566
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