早期CKD病人与正常老年人物质排泄率比较
发布时间：2019-06-07 11:30
【摘要】：目的：研究健康老年人生理性肾功能减退与相应eGFR水平的糖尿病肾脏病及高血压肾病患者肌酐、钙、钾、尿酸等物质排泄情况的差异。 方法：选取2012年-2013年山东省青岛市立医院肾内科以糖尿病及高血压病为原发病的CKD早期(12期)病人(CKD早期病人),正常老年组选取查体后筛选无肾脏病的70岁以上老年人,分别检测空腹血清中肌酐、尿酸、钙、钾,晨尿中肌酐、尿酸、钙、钾含量,计算eGFR及各物质排泄分数(FE),进行对比。 结果：将三组病人血清各物质浓度进行对比,如表2显示,三组病人血清TG,TC,LDL,血糖水平相当,无统计学差异(p0.05), CKD早期病人较大于70岁健康老年人血肌酐有显著差异(p0.01),但三组病人eGFR相当,无统计学差异(P0.05)。健康老年人血清尿酸较CKD早期病人低,血清胱抑素C,血钙水平较CKD早期病人水平高,有显著性差异(p0.01,p0.01, p0.01),三组病人血清钠无明显差异(p0.05)。CKD早期病人与健康老年人各物质排泄率比较,表3显示,FENa, FEC1升高,均有统计学意义(P0.05, P0.05)。FEK, FECa, FEUA无明显差异(p0.05, p0.05, p0.05)。 结论： 1.70岁以上健康老年人与以糖尿病及高血压病为原发病的早期CKD病人肾小球滤过率相当,但物质排泄存在差异,两者为不同的病理生理状态,临床上需区别对待。 2.同时平均年龄75岁的健康老年人肾脏功能处于CKD1-2期,而非先前认定的CKD3期。 3.对于高龄老年人,GFR的不同评估公式存在一定的差别,需要进一步的研究明确。
[Abstract]:Objective: to study the difference of creatinine, calcium, potassium and uric acid excretion between healthy elderly patients with physiological renal dysfunction and diabetic kidney disease and hypertensive nephropathy with corresponding eGFR level. Methods: from 2012 to 2013, early CKD patients (early CKD patients) with diabetes mellitus and hypertension as the primary disease in the Department of Nephrology, Qingdao Municipal Hospital of Shandong Province were selected. In the normal elderly group, the contents of serum creatinine, uric acid, calcium and potassium in fasting serum, creatine, uric acid, calcium and potassium in morning urine were measured after physical examination, and the excretion fraction of eGFR and (FE), were calculated. Make a comparison. Results: the serum concentrations of TG,TC,LDL, in the three groups were compared, as shown in Table 2, and there was no significant difference between the three groups (p0.05). The serum creatinine of early CKD patients was significantly higher than that of 70-year-old healthy elderly (p0.01), but there was no significant difference in eGFR among the three groups (P 0.05). The levels of serum uric acid and serum cystine C and calcium in healthy elderly patients were lower than those in early CKD patients, and the levels of serum cystine C and serum calcium in healthy elderly patients were significantly higher than those in early CKD patients (p0.01, p0.01). There was no significant difference in serum sodium among the three groups (p0.05). Compared with the healthy elderly, the excretion rate of each substance in the early patients with CKD was significantly higher than that in the healthy elderly. Table 3 showed that FENa, FEC1 was significantly higher (P0.05, P 0.05). FEK, FECa,). There was no significant difference in FEUA (p0.05, p0.05). Conclusion: 1. The glomerular filtration rate of healthy elderly over 70 years old is the same as that of early CKD patients with diabetes mellitus and hypertension, but there is difference in substance excretion. The two are different pathophysiological states and need to be treated differently in clinic. 2. two銆，
本文编号：2494760
[Abstract]:Objective: to study the difference of creatinine, calcium, potassium and uric acid excretion between healthy elderly patients with physiological renal dysfunction and diabetic kidney disease and hypertensive nephropathy with corresponding eGFR level. Methods: from 2012 to 2013, early CKD patients (early CKD patients) with diabetes mellitus and hypertension as the primary disease in the Department of Nephrology, Qingdao Municipal Hospital of Shandong Province were selected. In the normal elderly group, the contents of serum creatinine, uric acid, calcium and potassium in fasting serum, creatine, uric acid, calcium and potassium in morning urine were measured after physical examination, and the excretion fraction of eGFR and (FE), were calculated. Make a comparison. Results: the serum concentrations of TG,TC,LDL, in the three groups were compared, as shown in Table 2, and there was no significant difference between the three groups (p0.05). The serum creatinine of early CKD patients was significantly higher than that of 70-year-old healthy elderly (p0.01), but there was no significant difference in eGFR among the three groups (P 0.05). The levels of serum uric acid and serum cystine C and calcium in healthy elderly patients were lower than those in early CKD patients, and the levels of serum cystine C and serum calcium in healthy elderly patients were significantly higher than those in early CKD patients (p0.01, p0.01). There was no significant difference in serum sodium among the three groups (p0.05). Compared with the healthy elderly, the excretion rate of each substance in the early patients with CKD was significantly higher than that in the healthy elderly. Table 3 showed that FENa, FEC1 was significantly higher (P0.05, P 0.05). FEK, FECa,). There was no significant difference in FEUA (p0.05, p0.05). Conclusion: 1. The glomerular filtration rate of healthy elderly over 70 years old is the same as that of early CKD patients with diabetes mellitus and hypertension, but there is difference in substance excretion. The two are different pathophysiological states and need to be treated differently in clinic. 2. two銆，
本文编号：2494760
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