三联组氨酸核苷结合蛋白1及其在神经精神疾病中的功能

发布时间：2018-06-29 13:24

本文选题：三联组氨酸核苷结合蛋白 + 神经病理　；参考：《中国医学科学院学报》2017年05期

【摘要】：三联组氨酸核苷结合蛋白1(HINT1)是三联组氨酸(HIT)酶家族成员,作为核苷水解酶或转移酶起作用,其生物学功能尚不清楚。HINT1蛋白可在多种组织中表达,在转录和信号转导中发挥重要作用。早期研究已经明确HINT1是单倍剂量不足的肿瘤抑制因子;也有研究表明HINT1广泛参与一系列生理过程,且部分功能与其基本的酶活性无关;新近研究表明这一蛋白与诸多外周、中枢神经系统疾病存在密切关系,在遗传性周围神经病、精神分裂症、心境障碍、药物成瘾、唐氏综合征等神经精神疾病中起作用。本文针对HINT1蛋白在以上不同神经精神疾病中的作用做了详细综述,分析归纳了HINT1在上述每一种疾病中的研究发现,以期对今后该蛋白的深入研究起到一定的指导作用。
[Abstract]:Tri-histidine nucleoside binding protein 1 (HINT1) is a member of the triple histidine (hit) enzyme family, which acts as a nucleoside hydrolase or a transferase, and its biological function is not clear. HINT1 protein can be expressed in a variety of tissues. Play an important role in transcription and signal transduction. Earlier studies have identified HINT1 as a tumor suppressor with insufficient haplodose; others have shown that HINT1 is extensively involved in a series of physiological processes, and part of its function is not related to its basic enzyme activity; recent studies have shown that HINT1 is associated with many peripheral proteins. Central nervous system diseases are closely related to hereditary peripheral neuropathy, schizophrenia, mood disorders, drug addiction, Down's syndrome and other neuropsychiatric diseases. In this paper, the role of HINT1 protein in different neuropsychiatric diseases mentioned above is reviewed in detail, and the research findings of HINT1 in each of the above diseases are analyzed and summarized in order to play a guiding role in the further study of HINT1 protein in the future.
【作者单位】：西安交通大学医学部法医学院卫生部法医学重点实验室教育部环境与疾病相关基因重点实验室;陕西省人民医院心血管内科;马里兰大学药学院药物科学系;
【基金】：国家自然科学基金(81171262;81771435) 陕西省自然科学基础研究计划面上项目(2016JM8078)~~
【分类号】：R741

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