组织工程血管支架材料的研究与进展

发布时间：2018-07-23 16:02

【摘要】：背景:随着研究的深入,组织工程血管支架材料已由单纯的天然材料发展为可降解复合材料和纳米聚合物材料,其制备方法也由单纯手工发展到新兴的快速成型技术。目的:阐明不同组织工程血管支架材料的优缺点、用途及研究热点等,寻求一种能够符合临床需求的组织工程血管支架材料。方法:由第一作者检索1985至2015年PubM ed数据库、中国知网、维普中文期刊网等收录的与组织工程血管支架材料相关的文献。英文检索词为"tissue engineering,tissue engineered,blood vessel,vascular,scaffold",中文检索词为"组织工程;血管;支架材料;血管支架",按纳入、排除标准最后共纳入文献36篇进行综述。结果与结论:不可降解材料主要用于构建大口径组织工程血管;天然生物材料具有良好的生物相容性,能够提供细胞所需的信号,可促进细胞附着及保留分化功能;可降解高分子合成材料具有较好的组织相容性,机械性能、降解率和微结构可控,能根据设计要求进行批量生产;复合物材料结合了天然生物材料和合成高分子材料的优势,成为目前最理想的支架材料,也是未来研究的重点。
[Abstract]:Background: with the development of research, tissue engineering vascular scaffolds have been developed from pure natural materials to degradable composite materials and nano-polymer materials. The preparation methods of tissue engineering vascular scaffolds have also been developed from manual to emerging rapid prototyping technology. Objective: to clarify the advantages and disadvantages of different tissue engineering vascular stent materials, their applications and research topics, and to find a tissue engineering vascular stent material that can meet the clinical needs. Methods: from 1985 to 2015, the authors searched the PubM ed database, China knowledge Network, Weipu Chinese Journal Network and other documents related to tissue engineering vascular scaffold materials. The English key word is "tissue engineering / tissue engineering blood vessel / vessel scaffold", and the Chinese key word is "tissue engineering; blood vessel; stent material; vascular stent". According to the criteria of inclusion and exclusion, a total of 36 articles were reviewed. Results & conclusion: Non-degradable materials are mainly used to construct large caliber tissue engineering blood vessels, natural biomaterials have good biocompatibility, can provide necessary signals for cells, can promote cell adhesion and retain differentiation function. Biodegradable polymer synthetic materials have good histocompatibility, mechanical properties, degradation rate and microstructure controllable, and can be produced in batches according to the design requirements. The composite materials combine the advantages of natural biomaterials and synthetic polymer materials. To become the most ideal scaffold material, is also the focus of future research.
【作者单位】：昆明医科大学附属延安医院心脏大血管外科;云南省第一人民医院;
【基金】：云南省科技厅-昆明医科大学联合专项基金资助项目(2013FB187;2013FB189) 云南省卫生科技计划项目(2014NS208;2014NS209)~~
【分类号】：R318.08

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