微观结构与组织工程丝素支架研究进展

发布时间：2018-08-17 11:38

【摘要】：丝素蛋白因其具有良好的生物相容性、生物可降解性以及卓越的力学性能而被广泛应用于组织工程。为了促进丝素支架更利于细胞的黏附和增殖、促进新的细胞外基质生成、组织向内生长以及利于营养物质及代谢产物的运输等,丝素支架微观结构的构建仍是组织工程的一个重大挑战。本文着重围绕丝素支架的微观结构展开,介绍了多孔结构、纤维结构、多孔-纤维结构和水凝胶结构近年来在组织工程中的应用,从不同支架结构制备方法及功能方面并结合作者实验相关工作对比分析了不同支架结构的优势和存在的问题以及对细胞的影响,指出应从分子水平及原子水平上研究天然组织的结构来精准、有效地体外模拟构建组织工程丝素支架。
[Abstract]:Silk fibroin is widely used in tissue engineering because of its good biocompatibility, biodegradability and excellent mechanical properties. In order to promote the adhesion and proliferation of cells, promote the formation of new extracellular matrix, tissue growth to the inside and facilitate the transport of nutrients and metabolites, silk fibroin branch. The construction of scaffolds microstructure is still a major challenge in tissue engineering. This paper focuses on the microstructure of silk fibroin scaffolds. The applications of porous structure, fiber structure, porous-fiber structure and hydrogel structure in tissue engineering in recent years are introduced. The preparation methods and functions of different scaffolds are combined with the author's experimental phase. The advantages and disadvantages of different scaffolds and their effects on cells were compared and analyzed. It was pointed out that the structure of natural tissues should be studied at molecular and atomic levels to accurately and effectively simulate the construction of tissue engineered silk fibroin scaffolds in vitro.
【作者单位】：华侨大学化工学院化工与制药工程系;华侨大学生物材料与组织工程研究所;华侨大学化工学院生物工程与技术系;
【基金】：国家自然科学基金(31000441,31170939) 福建省高等学校杰出青年科研人才培育计划(JA12004) 福建省自然科学基金(2013J01189)项目
【分类号】：R318.08

【共引文献】