蚕丝丝素材料的生物降解性能

发布时间：2018-08-21 12:35

【摘要】：蚕丝丝素材料植入体内后的降解可直接造成其形态和结构变化、力学性能和质量下降。降解产物与组织反应或全身反应的程度密切相关。用于组织工程和再生医学的丝素支架材料的生物降解速率应与组织再生速率相匹配;用于药物控制释放系统的丝素载体的生物降解速率应与生物活性物质的释放需要相适应。概述了近年来对丝素材料生物降解问题的研究现状,介绍了通过体外、体内实验所观察到的丝素材料生物降解行为,包括天然丝素纤维、再生丝素纤维、多孔支架及薄膜等,总结了未来需要进一步研究的问题。指出蚕丝丝素作为一种蛋白质可被多种蛋白酶催化水解;天然丝素纤维比再生丝素材料的生物降解速率慢;丝素的分子构象、结晶度、交联程度、材料的形态等对丝素的降解速率有明显影响;建立预测丝素材料生物降解程度与其功能变化以及与机体应答关系的研究模型和技术,有效调控其生物降解速率,将是未来的研究方向。
[Abstract]:The degradation of silk fibroin material after implantation can directly cause the morphological and structural changes and decrease the mechanical properties and quality of silk fibroin material. The degradation product is closely related to the degree of tissue reaction or systemic reaction. The biodegradation rate of silk fibroin scaffolds for tissue engineering and regenerative medicine should be matched with the rate of tissue regeneration, and the biodegradation rate of silk fibroin carriers for drug controlled release system should be adapted to the release of bioactive substances. In this paper, the research status of biodegradation of silk fibroin materials in recent years is reviewed, and the biodegradation behaviors of silk fibroin materials observed in vitro and in vivo are introduced, including natural silk fiber, regenerated silk fiber, porous scaffold and film, etc. The problems that need further study in the future are summarized. It is pointed out that silk fibroin as a protein can be hydrolyzed by many proteases; the biodegradation rate of natural silk fibroin fiber is slower than that of regenerated silk fibroin material; the molecular conformation, crystallinity, and crosslinking degree of silk fibroin; The morphology of the material has a significant effect on the degradation rate of silk fibroin, and a research model and technology to predict the relationship between the biodegradation degree and the changes of the biodegradation degree and the response of the body are established to effectively regulate the biodegradation rate of silk fibroin. Will be the future research direction.
【作者单位】：苏州大学现代丝绸国家工程实验室;上海交通大学医学院附属瑞金医院烧伤科;苏州大学医学部免疫学系;
【基金】：国家自然科学基金资助项目(31370968) 江苏省基础研究计划(BK20131177)
【分类号】：R318.08

【参考文献】