用于乳腺癌灶边缘界定的阻抗测量系统研究

发布时间：2018-08-27 10:07

【摘要】：生物阻抗频谱特性携带着相当丰富的病理、生理信息。许多病理现象与生理活动都会导致人体局部组织阻抗的变化。将生物电阻抗技术应用于乳腺癌灶边缘界定具有广泛的发展前景,而且容易被人们接受。因其无创、快速和廉价等特点,多年来一直受到诸多专家学者的关注。本课题组在以往的研究工作中,优化了测量电极和测量方法,对离体乳腺组织的辨识做了大量深入的研究,并通过提取不同的特征参数,达到了很好的鉴别效果。本论文在以往的研究基础上,对特征参数提取的仪器频率适用范围做了进一步分析,并搭建了一套用于乳腺癌灶边缘界定的便携式阻抗测量系统,快速、准确地完成阻抗测量及对不同乳腺组织的鉴别。硬件系统采用模块化设计,包括信号源模块、解调模块、信号调理模块、数据采集模块和测量模块,并对各个模块做出了补偿和标定。由计算机控制信号源输出与数据采集的同步协调。论文参考Morimoto和Heinitz等人做法,对离体组织的阻抗测量数据进行三元件拟合,其测量的结果与Agilent4294A精密阻抗测量仪的测量结果对比,然后提取特征参数做进一步的验证。系统虽然存在一定误差,但是能够很好的跟踪不同模型的总体趋势,并且可以精确提取特征参数。最后,通过对猪肉的测量实验,验证了系统的灵敏性。
[Abstract]:Bioimpedance spectrum features carry a wealth of pathological and physiological information. Many pathological phenomena and physiological activities will lead to changes in local tissue impedance. The application of bioelectrical impedance technique to the determination of breast cancer foci has a wide range of prospects and is easily accepted by people. For its non-invasive, fast and cheap characteristics, many experts and scholars have been concerned for many years. In our previous research work, we optimized the measuring electrodes and methods, and made a lot of in-depth research on the identification of breast tissue in vitro, and achieved a good identification effect by extracting different characteristic parameters. On the basis of previous studies, this paper makes a further analysis of the application range of the instrument frequency for feature parameter extraction, and sets up a portable impedance measurement system for defining the edge of breast cancer focus. The impedance measurement and the identification of different breast tissues were completed accurately. The hardware system adopts modularization design, including signal source module, demodulation module, signal conditioning module, data acquisition module and measurement module, and makes compensation and calibration for each module. The synchronous coordination between the output of the signal source and the data acquisition is controlled by the computer. Referring to the methods of Morimoto and Heinitz, this paper carries out three element fitting of the impedance measurement data of isolated tissue. The measured results are compared with those of the Agilent4294A precision impedance meter, and then the characteristic parameters are extracted for further verification. Although the system has some errors, it can track the general trend of different models well and extract the feature parameters accurately. Finally, the sensitivity of the system is verified by measuring the pork.
【学位授予单位】：天津大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：TH776;R737.9

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