碳酸钠液相改性硅-磷酸钙复合骨水泥研究

发布时间：2018-08-30 11:48

【摘要】：以质量分数70%的硅酸三钙(Ca3SiO5,C3S)和30%磷酸氢钙(CaHPO4·2H2O,DCPD)复合得到的DCP30粉体材料为固相,以不同浓度碳酸钠溶液为液相,得到碳酸钠改性骨水泥材料。使用X射线衍射(XRD)、扫描电镜(SEM)、万能材料试验机等手段对不同浓度改性材料进行表征。结果显示:添加碳酸钠液相,骨水泥初、终凝时间分别缩短至16和55min;调控碳酸钠液相浓度,可以实现短期抗压强度优化;使用碳酸钠后,固化自发生成羟基磷灰石(HA)。浸泡模拟体液(SBF)7天,材料表面覆盖HA沉积层,生物活性优越。碳酸钠液相改性硅-磷酸钙复合骨水泥体系的水化性能、短期力学性能以及生物活性均优于Ca3SiO5水泥和未改性硅-磷酸钙复合骨水泥,是一种良好的生物活性骨修复材料。
[Abstract]:Using 70% tricalcium silicate (Ca3SiO5,C3S) and 30% CaHPO4 _ 2H _ 2O _ (DCPD) as solid phase and sodium carbonate solution as liquid phase, sodium carbonate modified bone cement material was obtained. The modified materials with different concentrations were characterized by means of X-ray diffraction (XRD),) scanning electron microscope (SEM),) universal material testing machine. The results showed that the initial setting time of bone cement was shortened to 16 and 55 minutes after adding sodium carbonate in liquid phase, the short-term compressive strength could be optimized by adjusting the liquid phase concentration of sodium carbonate, and hydroxyapatite (HA). Was formed spontaneously after the use of sodium carbonate. Immersing simulated body fluid (SBF) for 7 days, the surface of the material was covered with HA deposit layer, and the bioactivity was superior. The hydration, short-term mechanical properties and biological activity of sodium carbonate liquid modified silicon-calcium phosphate composite bone cement system are superior to those of Ca3SiO5 cement and unmodified silicon-calcium phosphate composite bone cement system. It is a good bioactive bone repair material.
【作者单位】：四川大学生物材料工程研究中心;
【基金】：国家重点基础研究发展计划(973计划)资助项目(2012CB933600) 国家自然科学基金资助项目(31070848) 高等学校博士学科点专项科研基金资助项目(20110181110064) 四川省创新团队资助项目(2011JTD0006) 江苏省生物医药功能材料协同创新中心项目
【分类号】：R318.08;O614.231

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