中年肺癌与老年肺癌临床特点对比研究

发布时间：2017-12-27 11:21

本文关键词：中年肺癌与老年肺癌临床特点对比研究　出处：《延安大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的:通过对2010年12月-2014年1月延安大学附属医院住院确诊的中年肺癌和老年肺癌患者相关临床资料进行回顾性分析,经统计学处理,探讨中、老年肺癌的临床特点,期望为肺癌的早期临床诊断提供帮助。方法:(1)调取2010年12月-2014年1月在延安大学附属医院住院并且经细胞学或病理学确诊的中年以上肺癌患者260例,其中中年组(45-59岁)128例(49.23%);老年组(60岁以上)132例(50.77%)。(2)回顾性分析所选患者的临床资料:包括性别、吸烟指数、首发临床表现、胸部CT表现,组织学类型以及临床分期。(3)采用SPASS19.0统计软件处理上述资料,计数资料用卡方检验,以P0.05为差异有统计学意义。结果:1.性别分布中年组:男82例(64.1%),女46例(35.9%);老年组:男94例(72.7%),女36例(27.3%),两者性别分布无显著性差异(p0.05),均以男性多见。2.吸烟指数中年组肺癌患者中吸烟指数"g400,62例(48.4%)、老年组肺癌患者中吸烟指数"g400,64例(48.5%),两者吸烟指数比较无显著性差异(p0.05),但均有较高吸烟史。3.临床表现中年组临床表现:咳嗽95例(74.2%)、气短52例(40.6%)、胸痛34例(26.6%)、其他14例(10.9%)、咯血8例(6.3%)、无症状1例(0.7%);老年组临床表现:咳嗽86例(65.2%)、气短42例(31.8%)、胸痛20例(15.2%)、其他22例(16.7%)、咯血10例(7.6%)、无症状2例(1.5%);两者临床表现无显著性差异。4.病理类型中年组:小细胞癌26例(20.60%)、腺癌50例(39.10%)、鳞癌46例(36.10%)、其他6例(4.2%);老年组:小细胞癌26例(19.40%)、腺癌40例(30.20%)、鳞癌50例(38.10%)、其他16例(12.30%)。两者病理类型分别比较无显著差异(p0.05),均以腺癌、鳞癌高发。5.临床分期(NSCLC)方面:中年组Ⅰ~Ⅲa期54例(64.2%),Ⅲb~Ⅳ期30例(35.71%);老年组肺癌患者Ⅰ~Ⅲa期46例(51.11%),Ⅲb~Ⅳ期44例(48.89%),两组患者临床分期经统计学比较,无显著性差异(p0.05)。6.中年组胸部CT表现:周围型40例(31.3%),中央型88例(68.7%);老年组胸部CT表现:周围型14例(10.67%),中央型118例(89.4%),经统计学分析,两组胸部CT表现有显著性差异,即中年组周围型肺癌发病率较老年组高,但二者均以中央型肺癌高发(p0.05)。结论:该项研究结果表明,中、老年肺癌在性别分布、吸烟指数、首发临床表现、病理分型、临床分期(非小细胞肺癌)等方面无显著性差异;仅在胸部CT表现方面,二者有显著性差异,即中年肺癌患者“周围型”肺癌发生率较老年更多见,但二者均以中央型肺癌为主。
[Abstract]:Objective: to middle-aged elderly patients with lung cancer lung cancer and related clinical data of December 2010 -2014 year in January in Affiliated Hospital of Yan'an University were analyzed retrospectively, after statistical treatment, to investigate the clinical characteristics of elderly patients with lung cancer, early diagnosis of lung cancer, expected to provide help. Methods: (1) 260 cases of middle-aged and above lung cancer diagnosed in Affiliated Hospital of Yan'an University in December 2010 January and diagnosed by cytology or pathology in January -2014 were enrolled. 128 cases (49.23%) were middle-aged group (45-59 years old), 132 cases (50.77%) were in the elderly group (60 years old or above). (2) retrospective analysis of the clinical data of selected patients, including sex, smoking index, first clinical manifestation, chest CT, histological type and clinical staging. (3) the SPASS19.0 statistical software was used to deal with the above data, and the counting data were checked with chi square, and the difference was statistically significant with the difference of P0.05. Results: 1., gender distribution in middle-aged group: 82 men (64.1%), 46 women (35.9%), the elderly group: 94 men (72.7%), 36 women (27.3%), there was no significant difference in gender distribution between them (P0.05), most of them were male. 2. smoking index in the middle-aged group, the smoking index in the lung cancer patients was g400,62 cases (48.4%), and the smoking index in the elderly group patients g400,64 (48.5%). There was no significant difference in the smoking index between the two groups (P0.05), but they all had a higher smoking history. 3. clinical manifestations of middle-aged group clinical manifestations: 95 cases of cough, shortness of breath (74.2%) of 52 cases (40.6%), 34 cases of chest pain (26.6%), the other 14 cases (10.9%), 8 cases of hemoptysis (6.3%), 1 cases without symptoms (0.7%); the clinical features of the aged group: 86 cases of cough, shortness of breath (65.2%) 42 cases (31.8%), 20 cases of chest pain (15.2%), the other 22 cases (16.7%), 10 cases of hemoptysis (7.6%), 2 cases without symptoms (1.5%); there was no significant difference of clinical manifestations. 4., pathological type of middle-aged group: small cell carcinoma in 26 cases (20.60%), adenocarcinoma in 50 cases (39.10%), squamous cell carcinoma in 46 cases (36.10%), and other 6 cases (4.2%); the elderly group: small cell carcinoma 26 cases (19.40%), adenocarcinoma 19.40% cases (19.40%), squamous cell carcinoma cases, and other cases. There was no significant difference in the pathological types of the two (P0.05), with high incidence of adenocarcinoma and squamous cell carcinoma. 5. clinical stage (NSCLC): middle age group I, III, a stage 54 cases (64.2%), stage III b~ IV stage 30 cases (35.71%); elderly group lung cancer patients with stage I III a stage 46 cases (51.11%), stage III b~ IV stage 44 cases (48.89%), two group patients clinical staging by statistical comparison, no significant difference (P0.05). 6. middle-aged group: chest CT manifestations of 40 cases were peripheral type (31.3%), 88 cases of central type (68.7%); the elderly group: chest CT manifestations of 14 cases were peripheral type (10.67%), 118 cases of central type (89.4%), by statistical analysis, two groups of chest CT showed significant differences, the middle age group around the onset lung cancer rate was higher than old age group, but the two are in central lung cancer (P0.05). Conclusion: the results of this study suggest that, in elderly patients with lung cancer in the clinical distribution of sex, smoking index, the first manifestation, pathological type, clinical stage (NSCLC) no significant differences; only in the chest CT findings, there was significant difference between the two, namely "peripheral" middle aged patients with lung cancer the incidence rate of lung cancer is more common in the elderly, but the two are mainly to central lung cancer.
【学位授予单位】：延安大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R734.2

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