分化型甲状腺癌肺转移相关危险因素分析

发布时间：2018-01-05 04:11

本文关键词：分化型甲状腺癌肺转移相关危险因素分析　出处：《广西医科大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：研究分化型甲状腺癌肺转移的相关危险因素。方法：选取2010年至2015年广西医科大学第一附属医院接受治疗的335例分化型甲状腺癌患者,回顾性分析其临床病理资料。探讨比较不同临床病理特征对分化型甲状腺癌发生肺转移的影响。通过131Ⅰ全身扫描、胸部CT或肺结节组织病理确诊肺转移。纳入所有患者性别、年龄、原发灶病理资料(病理类型、原发肿瘤最大直径、单灶或多灶、甲状腺包膜是否受侵犯、颈部淋巴结转移个数),并采用单因素分析和多因素Logistic回归分析研究分化型甲状腺癌发生肺转移的相关危险因素。结果：335例分化型甲状腺癌患者中,其中分化型甲状腺癌肺转移患者43例。单因素分析结果显示原发肿瘤病理类型(P=0.004)、原发肿瘤最大直径(P=0.001)、肿瘤数目多灶(P=0.001)、甲状腺包膜受侵犯(P=0.002)以及颈部淋巴结转移个数(P=0.001)可能与分化型甲状腺癌肺转移有关,而年龄(P=0.307)、性别(P=0.515)与分化型甲状腺癌肺转移无关。多因素Logistic回归分析结果显示原发肿瘤最大直径2cm(P=0.024,OR=1.258-7.135)、甲状腺包膜受侵犯(P=0.018,OR=1.141-12.552)、颈部淋巴结转移个数5个(P=0.023,OR=1.024-5.231)可能是分化型甲状腺癌肺转移的独立危险因素。结论：肿瘤直径2.0cm、甲状腺包膜受侵犯、颈部淋巴结转移数目5个可能是分化型甲状腺癌患者发生肺转移的独立危险因素。提示分化型甲状腺癌患者发生肺转移与上述临床病理学特征有密切联系。在手术后需重点关注这些临床指标,以早期诊断分化型甲状腺癌肺转移。
[Abstract]:Objective: to study the risk factors of lung metastasis in differentiated thyroid carcinoma. Methods: 335 patients with differentiated thyroid carcinoma received treatment from 2010 to 2015 in the first affiliated Hospital of Guangxi Medical University. The clinical and pathological data were analyzed retrospectively. The effects of different clinicopathological features on lung metastasis in differentiated thyroid carcinoma were compared. Chest CT or pulmonary nodule histopathological diagnosis of lung metastasis. All patients were included in the sex, age, primary pathological data (pathological type, primary tumor maximum diameter, single focus or multiple focus, thyroid capsule invasion or not. Cervical lymph node metastasis. Univariate analysis and multivariate Logistic regression analysis were used to study the risk factors of lung metastasis in differentiated thyroid carcinoma. The results of univariate analysis showed that the pathological type of the primary tumor was 0.004, and the maximum diameter of the primary tumor was 0.001). The number of tumors with multiple foci, thyroid capsule invasion (P0.002) and cervical lymph node metastasis (P0. 001) may be related to lung metastasis of differentiated thyroid carcinoma. The age was 0.307). The results of multivariate Logistic regression analysis showed that the maximum diameter of primary tumor was 2cm ~ (?) ~ (0.024). OR1. 258-7.135, P0. 018, 1. 141-12. 552, P0. 023 of cervical lymph node metastasis. OR1. 024-5. 231) may be an independent risk factor for lung metastasis of differentiated thyroid carcinoma. Conclusion: tumor diameter 2.0 cm, thyroid capsule invasion. The number of cervical lymph node metastasis may be an independent risk factor for lung metastasis in patients with differentiated thyroid carcinoma. It is suggested that lung metastasis in differentiated thyroid cancer patients is closely related to the above clinicopathological features. Postoperative attention should be paid to these clinical indicators. Early diagnosis of lung metastasis in differentiated thyroid carcinoma.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R736.1

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