68例尤文肉瘤家族临床特征及预后影响因素分析

发布时间：2018-01-24 11:58

本文关键词： 尤文肉瘤家族临床特征预后生存分析　出处：《广西医科大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的通过回顾分析广西医科大学附属肿瘤医院近13年来尤文肉瘤家族(the Ewing's sarcoma family of tumors,ESFT)患者的临床资料,分析可能影响患者预后的因素,旨在提高对该疾病的认识及积累诊疗经验。方法 1992年1月至2015年10月在广西医科大学附属肿瘤医院收治的、经病理确诊的ESFT患者68例临床资料,并进行统计学分析。结果ESFT患者68例,中位随访时间45.5个月(7-158个月)。该组患者发病中位年龄20岁(3-77岁),≤20岁占51.4%。中轴较四肢常见,比例分别为70.6%(48/68)、29.4%(20/68)。免疫组化CD99、FLI-1的阳性率分别为96.4%、92.3%。广泛期中位生存时间为12个月,局限期中位生存期为25个月。单因素分析表明治疗模式、是否化疗、临床分期是EFST预后相关的因素(三者P0.05)；多因素分析结果表明是否化疗、临床分期是独立预后影响因素(两者P0.05)。广泛期患者采用综合治疗模式生存时间优于单一治疗模式,两组间差异具有统计学意义(χ2=6.383,P=0.012),而局限期患者采用综合治疗模式与单一治疗模式的生存时间差异无统计学意义(χ2=2.698,P=0.101)。结论ESFT是一组高度恶性小圆细胞肿瘤,生存时间短,预后较差。是否化疗及临床分期是独立的预后因素。综合治疗可提高ESFT广泛期患者总生存期,是否改善局限期患者预后尚需更进一步研究。
[Abstract]:Objective To retrospectively analyze the Affiliated Tumor Hospital of Guangxi Medical University in recent 13 years (the Ewing's sarcoma family of Ewing's sarcoma family of tumors, ESFT) in patients with clinical data, analysis of possible factors affecting the prognosis of patients, and to improve the understanding of the disease and the accumulation of experience. Treatment methods from January 1992 to October 2015 in the Affiliated Tumor Hospital of Guangxi Medical University were treated by. The clinical data of 68 patients with pathologically confirmed ESFT patients were statistically analyzed. Results 68 cases of ESFT patients, the median follow-up time was 45.5 months (7-158 months). The patients with a median age of 20 years (3-77 years), less than 20 years old accounted for 51.4%. compared with the common axis of limbs, the ratio was 70.6% (48/68), 29.4% (20/68). The immunohistochemistry of CD99, the positive rate of FLI-1 is 96.4%, 92.3%. widely in median survival time was 12 months, the median survival period of limitation period for 25 months. The single factor analysis showed that treatment Model, whether chemotherapy, clinical stage are the prognostic factors in patients with EFST related (three P0.05); the results of multivariate analysis showed that chemotherapy, clinical stage were independent prognostic factors (both P0.05). Extensive patients with comprehensive treatment mode of survival time is better than a single treatment mode, the difference was statistically significant between the two groups (x2 2=6.383, P=0.012), there was no significant difference in survival time and period were treated with comprehensive treatment mode and single treatment mode (x 2=2.698, P=0.101). Conclusion ESFT is a group of highly malignant small round cell tumor, the survival time is short, poor prognosis. Chemotherapy and clinical stage were independent prognostic factors. Comprehensive treatment can improve the ESFT patients with overall survival, improve the prognosis of patients with limited stage whether still need further research.

【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R738

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