右美托咪定复合罗哌卡因在乳腺癌术后镇痛中的应用

发布时间：2018-01-30 04:55

本文关键词： 右美托咪定罗哌卡因肋间神经神经阻滞乳腺癌术后镇痛　出处：《广东医学》2017年03期 　论文类型：期刊论文

【摘要】：目的观察右美托咪定复合罗哌卡因肋间神经阻滞在乳腺癌术后镇痛的应用。方法 40例患者随机分为RD组和R组(n=20),RD组肋间神经阻滞用0.375%罗哌卡因20 m L复合右美托咪定1μg/kg;R组用0.375%罗哌卡因20 m L。记录术后0、0.5、1、2、4、8 h血流动力学变化;观察神经阻滞起效时间、镇痛持续时间及术后首次VAS评分,并记录不良反应。结果与R组相比,RD组患者注药后0.5、1、2、4 h心率减慢,差异有统计学意义(P0.05),罗哌卡因起效时间缩短,镇痛时间明显延长,首次VAS评分降低(P0.05),且口干发生率高。结论右美托咪定1μg/kg复合0.375%罗哌卡因20 m L肋间神经阻滞可以有效用于乳腺癌术后镇痛。
[Abstract]:Objective to observe the application of dexmetomidine combined with ropivacaine intercostal nerve block in postoperative analgesia of breast cancer. Methods Forty patients were randomly divided into Rd group and R group. In Rd group, 0.375% ropivacaine 20 mL combined with dexmetomidine 1 渭 g / kg was used for intercostal nerve block. Group R was treated with 0.375% ropivacaine (20 mL). The onset time of nerve block, the duration of analgesia and the first VAS score after operation were observed, and the adverse reactions were recorded. Results compared with R group, the heart rate of Rd group was significantly slower than that of R group. The difference was statistically significant (P 0.05). The onset time of ropivacaine was shortened, the analgesia time was significantly prolonged, and the first VAS score was decreased (P 0.05). Conclusion 1 渭 g / kg dexmetomidine combined with 0.375% ropivacaine 20 mL intercostal nerve block can be used for postoperative analgesia of breast cancer.
【作者单位】：淮安市妇幼保健院麻醉科;
【分类号】：R614;R737.9
【正文快照】： 乳腺癌术后由于切口长、敷料对伤口压迫、患者紧张焦虑等因素常需要术后镇痛,静脉镇痛常导致恶心呕吐等不良反应,因此选择合适的镇痛方法和药物很重要。右美托咪定(dexmedetomidine,Dex)是一种高选择性α2受体激动剂,具有镇静镇痛双重功能,将其复合罗哌卡因用于臂丛神经阻滞,

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