独活补骨方联合唑来膦酸治疗恶性肿瘤骨转移的临床观察

发布时间：2018-01-31 23:52

本文关键词： 恶性肿瘤骨转移独活补骨方唑来膦酸　出处：《南京中医药大学学报》2017年02期 　论文类型：期刊论文

【摘要】：目的观察中药独活补骨方联合唑来膦酸治疗恶性肿瘤骨转移的临床疗效。方法选择2014年9月-2016年2月重庆市中医院肿瘤科收治的恶性肿瘤骨转移患者50例,随机分为观察组和对照组,2组均采用唑来膦酸治疗,观察组加用中药独活补骨方口服。观察2组止痛效果、止痛药用量及治疗前后生活质量评分(KPS)变化情况,用ELISA法测定治疗前后尿Ⅰ型胶原氨基末端肽(NTX)、血骨碱性磷酸酶(BALP)。结果观察组治疗后止痛药用量较对照组明显减少(P0.05),KPS较对照组明显提高(P0.05),2组治疗后疼痛评分(NRS)变化无显著差异(P0.05),治疗组治疗后尿NTX、血BALP水平较治疗前降低(P0.01),但与对照组比较,差异无统计学意义(P0.05)。结论中药联合唑来膦酸是恶性肿瘤骨转移的有效治疗方式,中药能有效提高止痛效果,减少止痛药用量,提高患者生活质量,对改善肿瘤骨破坏具有协同作用的趋势。
[Abstract]:Objective to observe the clinical effect of Duhubugu recipe combined with zoledronic acid on bone metastasis of malignant tumor. Methods from September 2014 to February 2016, the malignant tumor bone metastases were selected from the Department of Oncology, Chongqing traditional Chinese Medicine Hospital. There were 50 patients. They were randomly divided into two groups: the observation group and the control group were treated with zoledronic acid, and the observation group was treated with the traditional Chinese medicine Duhubugu decoction orally, and the analgesic effect of the two groups was observed. Before and after treatment, the dosage of painkillers and the quality of life (QOL) scores were measured by ELISA method. The urinary type I collagen amino-terminal peptide (NTX) was determined before and after treatment. Results the dosage of analgesic drugs in the observation group was significantly lower than that in the control group (P 0.05) and KPS was significantly higher than that in the control group (P 0.05). There was no significant difference in pain score after treatment between the two groups (P 0.05). After treatment, the levels of urinary NTX and blood BALP in the treatment group were lower than those before treatment, but compared with those in the control group. Conclusion traditional Chinese medicine combined with zoledronic acid is an effective treatment for bone metastasis of malignant tumors. Traditional Chinese medicine can effectively improve the analgesic effect and reduce the dosage of analgesic drugs. Improving the quality of life of patients has a synergistic effect on the improvement of tumor bone destruction.
【作者单位】：重庆市中医院肿瘤科;
【基金】：重庆市卫计委科研项目(zr20150238)
【分类号】：R738.1
【正文快照】： 骨是除肺和肝以外,恶性肿瘤最常见的转移部位,约70%~80%的癌症患者最终会发生骨转移。随着抗癌治疗的进展,晚期癌症患者中位生存时间逐渐延长,生存获益的同时发生骨转移及骨相关事件(SRE)的风险亦随之增高[1]。早期诊断、多学科综合治疗,将会极大地改善患者的预后,提高患者的

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