结肠肿瘤干细胞巢研究——从潘氏细胞谈起

发布时间：2018-02-05 22:55

本文关键词： 肿瘤干细胞巢结肠癌潘氏细胞信号通路　出处：《肿瘤防治研究》2017年02期 　论文类型：期刊论文

【摘要】：近年来,对肿瘤干细胞巢的深入研究开启了肿瘤研究的"巢"时代,结直肠癌是实体肿瘤的典型代表,有较为典型的发生发展机制,是肿瘤干细胞巢研究的可靠模型。潘氏细胞是正常肠上皮的重要组成细胞,对肠干细胞具有重要的支持、保护等作用,是肠干细胞巢的关键成分之一。然而目前在结肠上皮恶性转化中,以潘氏细胞为代表的干细胞巢成分的作用如何尚有待研究,进一步研究潘氏细胞和肠干细胞的相互关系,从而推导其在结肠肿瘤不同发展阶段的可能作用,将有助于对肿瘤干细胞巢的进一步了解,同时也可为结直肠癌临床治疗提供潜在的新靶点。
[Abstract]:In recent years, research on tumor stem cell niche opens the cancer research "nest" era, colorectal cancer is the typical representative of solid tumors, a mechanism of the occurrence and development of the typical model is reliable, the cancer stem cell research. Nest Paneth cells are normal intestinal epithelial cells to form, has an important support for intestinal stem cell, protective effect, is one of the key ingredients of intestinal stem cell niches. However, in colonic epithelial malignant transformation, to Paneth cells as the representative of the stem cell niche component role remains to be further studied, to further study the relationship between Paneth cells and intestinal stem cells, which are in the the possible role of colon cancer in different stages of development, would help to further understand the tumor stem cell nests, but also provide a potential new target for clinical treatment of colorectal cancer.

【作者单位】：中国人民解放军总医院海南分院肿瘤科;中国人民解放军94528部队医院门诊部;
【基金】：国家自然科学基金(81503391)
【分类号】：R735.35

【相似文献】