EGFR蛋白表达水平与结直肠癌放疗敏感性的相关性

发布时间：2018-02-11 22:12

本文关键词： 结直肠癌表皮生长因子受体(EGFR) 免疫组化放疗敏感性　出处：《基因组学与应用生物学》2017年09期 　论文类型：期刊论文

【摘要】：为探讨表皮生长因子受体(EGFR)蛋白表达水平与结直肠癌放疗敏感性的相关性。选取我院2014年1月至2014年12月期间肛肠外科收治的50例局部进展期中低位结直肠癌患者,所有患者均接受放疗和直肠全系膜切除并达Ro切除治疗,均保留放疗前后的直肠癌组织病理标本,通过免疫组化SP法检测观察放疗前后病理表本中EGFR蛋白表达变化,根据肿瘤病理消退结果评估放疗敏感性,分析EGFR蛋白表达和放疗敏感性的的关系。50例患者放疗前后病理组织EGFR蛋白表达变化差异无统计学意义(p0.05),放疗后13例EGFR蛋白表达降低,21例表达无变化,16例表达升高;放疗后肿瘤病理消退42.00%(21/50),58.00%(29/50)患者病理消退并不明显;肿瘤病理消退单因素分析显示放疗方案、放疗总量、放疗前EGFR蛋白表达、放疗后EGFR蛋白表达变化是放疗敏感性的影响因素(x2=8.324,6.721,6.324,5.721,均p0.05);多因素Logistic回归分析显示放疗方案、放疗前后EGFR蛋白表达变化是放疗敏感性的独立影响因素(OR=2.547,19.824,均p0.05),放疗后EGFR蛋白表达升高提示结直肠癌患者放疗抵抗。结直肠癌患者放疗后病理组织EGFR蛋白表达变化不一,而放疗前后EGFR蛋白表达水平变化是放疗敏感性的独立影响因素。
[Abstract]:To investigate the correlation between the expression of epidermal growth factor receptor (EGFR) protein and the radiosensitivity of colorectal cancer, 50 patients with locally advanced low colorectal cancer were selected from January 2014 to December 2014 in our hospital. All patients were treated with radiotherapy, total mesorectal excision and Ro resection. The pathological specimens of rectal cancer were preserved before and after radiotherapy. Immunohistochemical SP method was used to detect the expression of EGFR protein in the pathological surface before and after radiotherapy. The radiosensitivity was evaluated according to the results of tumor pathological regression. The relationship between the expression of EGFR protein and radiosensitivity was analyzed. There was no significant difference in the expression of EGFR protein in pathological tissues before and after radiotherapy in 50 patients. The expression of EGFR protein decreased in 13 cases and increased in 16 cases after radiotherapy. The pathological regression of tumor after radiotherapy was 42.00% and 58.00% 58.00% (29 / 50). The univariate analysis of tumor pathological regression showed that the radiotherapy scheme, the total amount of radiotherapy, the expression of EGFR protein before radiotherapy, The change of EGFR protein expression after radiotherapy was the influencing factor of radiosensitivity. The multivariate Logistic regression analysis showed the radiotherapy regimen. The change of EGFR protein expression before and after radiotherapy was an independent influencing factor of radiosensitivity. The expression of EGFR protein increased after radiotherapy, indicating that the expression of EGFR protein was resistant to radiotherapy in patients with colorectal cancer, but the expression of EGFR protein in pathological tissues of patients with colorectal cancer was different after radiotherapy. The change of EGFR protein expression before and after radiotherapy was an independent factor of radiosensitivity.
【作者单位】：黄冈职业技术学院;
【基金】：黄冈职业技术学院资助
【分类号】：R735.34

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