86例初诊多发性骨髓瘤患者血钙水平的临床分析

发布时间：2018-02-16 12:48

本文关键词： 多发性骨髓瘤血钙水平临床特征　出处：《兰州大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的研究86例初诊多发性骨髓瘤(Multiple Myeloma,MM)患者血钙水平的异常及血钙与临床特征的相关性。方法回顾性分析我院2009年至2016年收治的86例初诊多发性骨髓瘤患者的临床资料,收集患者性别、年龄、血红蛋白、白蛋白、球蛋白、肌酐、尿酸、血磷、β2-微球蛋白、免疫分型及疾病分期等临床数据,将血钙进行校正并分组:低血钙(2.20mmol/L),正常血钙(2.20~2.60mmol/L)和高血钙(2.60 mmol/L)。分析患者临床特征与血钙水平之间的相关性,比较低钙组与非低钙组的临床特征。结果多发性骨髓瘤患者低血钙、正常血钙及高血钙组病例数校正前分别为58例(67.4%)、18例(20.9%)及10例(11.6%),校正后分别为34例(39.5%)、36例(41.9%)及16例(18.6%),经校正后低钙组占34例(39.5%),正常钙组36例(41.9%),高血钙16例(18.6%);年龄、球蛋白、肌酐、尿酸、血磷与血钙水平呈不同程度正相关,而性别、血红蛋白、白蛋白和β2-微球蛋白与血钙水平无关;低钙组与非低钙组的发病年龄,球蛋白、肌酐及血磷水平差异显著(P0.05),而性别、血红蛋白、白蛋白、尿酸、β2-微球蛋白、免疫分型及临床分期无差异(P0.05)。结论1.多发性骨髓瘤患者存在高钙血症,也存在低钙血症,低钙血症的发生率较高。2.多发性骨髓瘤患者血钙水平与年龄、球蛋白、肌酐、尿酸、血磷有关。3.多发性骨髓瘤患者血钙紊乱的具体机制有待进一步研究。
[Abstract]:Objective to study the abnormal level of serum calcium in 86 newly diagnosed patients with multiple myeloma (MM) and the correlation between serum calcium and clinical features. Methods the clinical data of 86 newly diagnosed patients with multiple myeloma from 2009 to 2016 in our hospital were retrospectively analyzed. The clinical data including sex, age, hemoglobin, albumin, globulin, creatinine, uric acid, serum phosphorus, 尾 _ 2-microglobulin, immunological classification and disease stage were collected. Blood calcium was adjusted and divided into two groups: hypocalcemia 2.20 mmol / L, normal blood calcium 2.20 卤2.60 mmol / L) and hypercalcemia 2.60 mmol / L. The correlation between clinical characteristics and serum calcium levels was analyzed to compare the clinical characteristics between low calcium group and non-low calcium group. Results low serum calcium was found in multiple myeloma patients. The number of cases in normal and hypercalcemia groups was 58 cases before correction, including 18 cases with 20. 9% and 10 cases with 11. 6K, respectively. After correction, 34 cases (39. 5%) and 16 cases were Rhizoma Musca.) after correction, 34 cases in low calcium group accounted for 39. 5%, 36 cases in normal calcium group (41. 9%), 16 cases in hypercalcemia group (18. 6m); age, globulin, creatinine, creatinine, hirsurea; age, globulin, creatinine, creatinine in 36 cases; hypercalcemia in 16 cases; age, globulin, creatinine, creatinine in 18. 6%; age, globulin, creatinine, creatinine. Uric acid, serum phosphorus and serum calcium levels were positively correlated to different degrees, but gender, hemoglobin, albumin and 尾 _ 2-microglobulin were not correlated with serum calcium level, and the age of onset, globulin, globulin in low calcium group and non-low calcium group were not related to serum calcium level. There was no significant difference in creatinine and serum phosphorus levels (P 0.05), but there was no significant difference in sex, hemoglobin, albumin, uric acid, 尾 2-microglobulin, immunophenotype and clinical staging. Conclusion 1.There are hypercalcemia and hypocalcemia in patients with multiple myeloma. The incidence of hypocalcemia is high .2. the relationship between serum calcium level and age, globulin, creatinine, uric acid, blood phosphorus in patients with multiple myeloma needs further study.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R733.3

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