前列腺癌的IVIM-DWI及其与MVD的相关性分析

发布时间：2018-02-24 22:06

本文关键词： 体素内不相干运动弥散加权成像前列腺癌良性前列腺增生 MVD　出处：《暨南大学学报(自然科学与医学版)》2017年04期 　论文类型：期刊论文

【摘要】：目的:探讨体素内不相干运动弥散加权成像(IVIM-DWI)技术在前列腺癌中的诊断价值,并结合CD34病理染色结果,分析IVIM-DWI各灌注相关参数的病理生理学基础.方法:采用3.0T核磁共振对符合纳入标准的前列腺癌患者(PCa组)24例[平均年龄(74.29±7.77)岁]及良性前列腺增生患者(BPH组)21例[平均年龄(70.48±9.40)岁],行IVIM-DWI检查,应用经典双指数函数模型对所得数据进行处理分析得到相关定量参数D、D*、f值.对行根治性切除手术的前列腺癌及良性前列腺增生患者的病理切片行CD34染色并计算微血管密度(MVD).结果:PCa组中D值及f值较BPH组明显减低,而D*值明显升高,差异有统计学意义(P0.05).PCa组中D*值与MVD显著正相关(r=0.793,P0.05),BPH组中f值与MVD显著正相关(r=0.766,P0.05).结论:IVIM-DWI各相关参数(D、D*、f值)在前列腺癌与良性前列腺增生的鉴别中具有明确的诊断价值.前列腺癌中D*值的升高与前列腺癌组织内微血管密度密切相关,而f值的减低可能与癌灶中血管通透性的异常有关.
[Abstract]:Objective: to investigate the diagnostic value of IVIM-DWI technique in prostate cancer with intra voxel incoherent motion diffusion weighted imaging (DWI), and to evaluate the diagnostic value of IVIM-DWI combined with CD34 pathological staining. The pathophysiological basis of perfusion related parameters of IVIM-DWI was analyzed. Methods: Twenty-four patients (mean age: 74.29 卤7.77) and 21 patients with benign prostatic hyperplasia (BPH) and benign prostatic hyperplasia (BPH) group were treated with 3.0T MRI in PCA group [mean age: 74.29 卤7.77 years] and benign prostatic hyperplasia group (n = 21). The average age was 70.48 卤9.40 years old. IVIM-DWI examination was performed. Using the classical double exponential function model to process and analyze the data, the relevant quantitative parameters were obtained. The pathological sections of patients with prostate cancer and benign prostatic hyperplasia undergoing radical resection were stained with CD34 and calculated microscopically. Results the D and f values of the BPH group were significantly lower than those of the BPH group. However, the value of D * was significantly increased, There was a significant positive correlation between D * value and MVD in P0.05U 路PCA group. Conclusion there is a definite diagnostic value in the differential diagnosis between prostate cancer and benign prostatic hyperplasia (P < 0.05). There is a significant positive correlation between f value in MVD group and 0.766P0.05 value in MVD group. Conclusion: the D ~ * value of MVD group is significant in differential diagnosis of prostate cancer and benign prostatic hyperplasia (P = 0.76 6 P 0.05 P < 0.05). Conclusion: t IVIM-DWI has a definite diagnostic value in the differential diagnosis of prostate cancer and benign prostatic hyperplasia (BPH). The increase of D * value in prostate cancer was closely related to the microvessel density in prostate cancer tissue. The decrease of F value may be related to the abnormal vascular permeability in cancer focus.
【作者单位】：暨南大学附属第一医院医学教育培训部;暨南大学附属第一医院医学影像中心;
【基金】：广东省科技计划项目(2013B021800161)
【分类号】：R445.2;R737.25

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