宫颈上皮内瘤变与生殖道感染的关系

发布时间：2018-02-25 00:16

  本文关键词： 宫颈上皮内瘤变 滴虫 沙眼衣原体 解脲脲原体 人乳头瘤病毒　出处：《中华医院感染学杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的探讨宫颈上皮内瘤变(CIN)与生殖道滴虫、细菌性阴道病、沙眼衣原体、解脲脲原体、人乳头瘤病毒(HPV)感染的关系。方法选择医院妇科2014年1月-2015年12月宫颈CIN患者300例为CIN组,宫颈上皮正常者300例为对照组,检测生殖道滴虫、细菌性阴道病、沙眼衣原体、解脲脲原体、HPV感染情况。结果 CIN组滴虫、细菌性阴道病、沙眼衣原体、解脲脲原体、HPV16/18感染率(25.3%、29.3%、29.0%、53.0%、75.0%)均高于对照组(13.0%、14.7%、7.3%、43.7%、4.0%)(P0.05);CINⅠ亚组、CINⅡ亚组、CINⅢ亚组之间生殖道滴虫、细菌性阴道病、沙眼衣原体、解脲脲原体感染率比较差异无统计学意义,CINⅡ亚组、CINⅢ亚组HPV16/18感染率(83.5%、92.4%)均明显高于CINⅠ亚组(55.9%),但CINⅡ亚组和CINⅢ亚组HPV16/18感染率比较差异无统计学意义;CIN组HPV16/18感染合并滴虫感染、HPV16/18感染合并细菌性阴道病、HPV16/18感染合并沙眼衣原体、HPV16/18感染合并解脲脲原体的发生率(6.7%、11.7%、18.0%、40.3%)均高于对照组(0.3%、0.3%、1.0%、1.7%)(P0.05);生殖道HPV16/18感染与滴虫、细菌性阴道病、沙眼衣原体感染呈正相关(r=0.013、0.020、0.027,P0.05),和解脲脲原体感染无显著相关性。结论宫颈CIN与生殖道滴虫、细菌性阴道病、沙眼衣原体、解脲脲原体、HPV16/18感染有关,HPV16/18感染与病情进展有关,与生殖道滴虫、细菌性阴道病、沙眼衣原体感染呈正相关。
[Abstract]:Objective to investigate the relationship between cervical intraepithelial neoplasia (cin) and genital trichomonas, bacterial vaginosis, chlamydia trachomatis, Ureaplasma Urealyticum. Methods three hundred patients with cervical CIN from January 2014 to December 2015 were selected as CIN group and 300 normal cervix epithelium as control group. Trichomonad, bacterial vaginosis and chlamydia trachomatis were detected. Results the infection rates of trichomonad, bacterial vaginosis, chlamydia trachomatis and HPV16 / 18 in CIN group were higher than those in the control group. Chlamydia trachomatis, There was no significant difference in Ureaplasma Urealyticum infection rate. The HPV16/18 infection rate in cin 鈪，

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