羟考酮联合加巴喷丁用于重度癌痛患者的长期疗效及满意度

发布时间：2018-02-26 03:18

本文关键词： 羟考酮加巴喷丁镇痛药日均费用癌痛生活质量　出处：《中国新药与临床杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的观察羟考酮联合加巴喷丁用于癌痛患者的镇痛效果及患者满意度。方法选择60例疼痛视觉模拟量表(VAS)评分7分以上的癌痛患者经吗啡滴定后随机分为两组,每组30例。对照组给予羟考酮的基础上加服安慰剂,试验组给予羟考酮的基础上加服加巴喷丁。观察比较患者服药前后VAS评分,及服药后1周和1、3、6个月羟考酮的日剂量、日止痛药费用、生活质量评分。结果 1个月后,两组患者羟考酮日均剂量差异无显著意义(P0.05);3个月后,对照组羟考酮日均剂量显著高于试验组[(58.0±15.2)mg vs.(33.4±11.0)mg,P0.001];试验组日均止痛药费用则明显低于对照组[(34.5±10.2)元vs.(52.4±13.7)元,P0.01];两组患者服药后各时间点生活质量评分均较治疗前增加(P0.05);试验组3个月后和6个月后生活质量评分均高于对照组(分别为46.8±4.5 vs.43.5±4.6,P=0.007和46.5±4.8 vs.41.4±4.3,P0.001)。两组患者嗜睡和头晕的发生率相似(P0.05),而对照组恶心、呕吐(P=0.038)和便秘(P0.001)的发生率显著高于试验组。结论重度癌痛患者采用羟考酮联合加巴喷丁有利于控制疼痛,降低羟考酮的用量,减少止痛药物费用,并且有利于减少恶心、呕吐和便秘的发生率,改善生活质量。
[Abstract]:Objective to observe the analgesic effect and patient satisfaction of patients with cancer pain treated with hydroxycodone combined with batapentin. Methods 60 patients with cancer pain with visual analogue pain scale (VASS) score of 7 or more were randomly divided into two groups after morphine titration. There were 30 patients in each group. The control group was given hydroxycodone plus placebo, and the trial group was given hydroxycodone plus gabapentine. The VAS scores of patients before and after administration were observed and compared, and the daily dose of hydroxycodone 1 week and 1 3, 6 months after administration were observed and compared. Results after one month, there was no significant difference in the daily average dose of hydroxycodone between the two groups, and after 3 months, there was no significant difference between the two groups. The average daily dose of hydroxycodone in the control group was significantly higher than that in the test group [58.0 卤15.2mg vs.(33.4 卤11.0mg / g P0.001], and the average daily painkiller cost in the test group was significantly lower than that in the control group [34.5 卤10.2 yuan vs.(52.4 卤13.7 yuan P0.01]. After 3 months and 6 months, the scores of quality of life were higher than those of the control group (46.8 卤4.5 vs.43.5 卤4.6 vs.43.5, P 0.007 and 46.5 卤4.8 vs.41.4 卤4.3 vs.41.4 卤4.3 vs.41.4 卤4.3 vs.41.4 卤0.001g, respectively). The incidence of drowsiness and dizziness in the two groups was similar to that in the control group (P 0.05), while in the control group, the incidence of drowsiness and dizziness was similar. The incidence of vomiting and constipation in patients with severe cancer pain was significantly higher than that in the trial group. Conclusion it is beneficial to control pain, reduce the dosage of hydroxycodone, reduce the cost of painkillers and reduce nausea in patients with severe cancer pain. The incidence of vomiting and constipation improves the quality of life.
【作者单位】：绍兴市人民医院麻醉科;绍兴市人民医院医学研究中心;绍兴市人民医院重症医学科;
【基金】：浙江省自然基金(LY15H030013) 浙江省卫生厅项目(2016KYB197)
【分类号】：R730.5

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