NK细胞应用于肿瘤免疫治疗的研究进展

发布时间：2018-02-26 05:20

本文关键词： NK细胞免疫治疗免疫球蛋白样受体嵌合抗原受体免疫检查点抑制剂　出处：《现代免疫学》2017年03期 　论文类型：期刊论文

【摘要】：NK细胞作为固有免疫细胞,它的激活无MHC限制也不需预先致敏,其在肿瘤免疫治疗中的作用受到越来越多的关注。然而,在肿瘤发生过程中,肿瘤细胞依然可以逃避NK细胞的杀伤,相关机制也各有报道。为了解决此问题,近年来,在增强NK细胞抗肿瘤活性和提高NK细胞特异性杀伤肿瘤方面取得了令人瞩目的研究成果。这提示NK细胞在肿瘤免疫治疗中具有广阔的应用前景。本文主要对抗体介导的NK细胞、与受者杀伤细胞KIR不匹配的同种异体NK细胞、嵌合抗原受体介导的NK细胞和免疫检查点抑制剂联合NK细胞对肿瘤细胞的细胞毒活性进行归纳与总结,以期为后续肿瘤免疫治疗相关基础和临床应用研究提供较为清晰的思路和参考。
[Abstract]:As innate immune cells, NK cells are activated without MHC restriction and need not be sensitized in advance. The role of NK cells in tumor immunotherapy has attracted more and more attention. However, in the process of tumorigenesis, NK cells have attracted more and more attention. Tumor cells can still escape the killing of NK cells, and the related mechanisms have been reported. In order to solve this problem, in recent years, Great achievements have been made in enhancing the anti-tumor activity of NK cells and enhancing the specific cytotoxicity of NK cells, which indicates that NK cells have a broad application prospect in tumor immunotherapy. The cytotoxic activity of allogeneic NK cells, chimeric antigen receptor-mediated NK cells and immunocheckpoint inhibitors combined with NK cells against tumor cells was summarized and summarized. In order to provide a clear idea and reference for the follow-up tumor immunotherapy related basic and clinical application research.
【作者单位】：西北工业大学生命学院空间生物实验模拟技术重点实验室;
【基金】：西北工业大学2016年度研究生创意新种子基金(Z2016196) 陕西省自然科学基金项目(2015JQ3083) 国家自然科学基金青年基金项目(81502465) 中央高校基本科研业务费专项资金资助(3102014JCQ15001)
【分类号】：R730.51

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