显微镜及神经内镜下经鼻蝶垂体瘤切除术术后嗅觉功能障碍对比分析

发布时间：2018-02-26 07:41

  本文关键词： 垂体腺瘤 经鼻蝶手术 嗅觉 神经内镜 显微镜　出处：《临床耳鼻咽喉头颈外科杂志》2017年19期 　论文类型：期刊论文

【摘要】：目的:探讨显微镜下经鼻蝶窦入路(MTS)及神经内镜技术(ETS)下经鼻蝶入路术后出现嗅觉功能障碍的相关因素,以进一步指导临床诊治。方法:在回顾性研究中,对入组患者进行病例资料分析,并进行电话随访,记录术前术后嗅觉情况;利用五味试嗅液检测方法对前瞻性研究中的入组患者进行术前,术后1周、1个月、3个月、6个月检查,将结果进行统计学分析。结果:回顾性研究中,MTS组、ETS组患者术后嗅觉障碍发生率分别为67.74%和47.37%,差异无统计学意义(P0.05),对可能的相关因素进行统计学分析,结果显示差异均无统计学意义。前瞻性研究中,ETS和MTS组术侧鼻腔、非术侧鼻腔的术前及术后结果之间、术后3次结果之间差异均有统计学意义(P0.05);4次检查结果中,ETS组和MTS组患者各自术侧鼻腔与非术侧比较,差异无统计学意义(P0.05)。结论:经鼻蝶手术入路切除垂体瘤术后会出现嗅觉功能障碍,积极做好术前鼻腔准备,术中尽可能保护鼻腔结构完整,术后给予适当处理,可能会降低嗅觉障碍发生率。
[Abstract]:Objective: to investigate the related factors of olfactory dysfunction after transsphenoidal approach (MTS) under microscope and endoscopic approach (ETS) in order to guide the clinical diagnosis and treatment. Case data were analyzed and telephone follow-up was conducted to record the olfactory status before and after operation, and the patients in prospective study were examined before operation, 1 week, 1 month, 3 months and 6 months after operation by using the method of five flavor test olfactory fluid detection, and the results were as follows: 1 week, 1 month, 3 months and 6 months after operation. Results: the incidence of postoperative olfactory disorders in MTS group was 67.74% and 47.37, respectively. There was no significant difference (P 0.05). The possible related factors were analyzed statistically. The results showed that there was no significant difference between the preoperative and postoperative results of the two groups in prospective study. There were significant differences among the three postoperative results (P 0.05). The nasal cavity of the patients in the MTS group and the MTS group were compared with those in the non-operative side. Conclusion: after transsphenoidal resection of pituitary adenoma, olfactory dysfunction will occur, the nasal cavity should be prepared before operation, the structure of nasal cavity should be protected as much as possible, and the proper treatment should be given after operation. May reduce the incidence of olfactory disorders.
【作者单位】： 宁夏医科大学总医院神经外科;宁夏医科大学总医院肝胆外科;山东省冠县中心医院脑电图室;邢台市人民医院神经外科;
【分类号】：R736.4
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本文编号：1537143