高频ns脉冲串作用下肝脏肿瘤热效应的多参数有限元仿真

发布时间：2018-02-26 11:24

  本文关键词： 温度 热损伤 肿瘤 高频ns脉冲串 Pennes生物传热方程 有限元　出处：《高电压技术》2017年08期 　论文类型：期刊论文

【摘要】：为了综合传统不可逆电穿孔和ns脉冲的特点,充分发挥脉冲电场非热治疗肿瘤的优势,将高频ns脉冲串引入到消融肿瘤组织的应用中,并研究了此高频ns脉冲串在生物组织中产生的热效应。通过多参数有限元方法对施加1对针电极的肝脏和肿瘤组织的温度以及热损伤进行了仿真,施加的电压范围为1~4 k V,脉冲宽度范围为50~500 ns,重复频率介于100 k Hz~1 MHz之间,脉冲串长度为100μs,脉冲串的重复频率为1 Hz。使用Pennes生物传热方程计算电热耦合下的温度,并根据Arrhenius公式计算热损伤。结果表明:肿瘤在单个脉冲串作用下在100μs时刻达到的最高温度为49.26℃;在1 s时刻最高温度为40.4℃,经过1 s时刻之后热损伤的累积程度只有0.001 6,不会造成热损伤;通过参数拟合,可以得到任意参数下的组织温度以及热损伤。研究结果可为将来的实验研究提供参数选择的理论依据。
[Abstract]:In order to integrate the characteristics of traditional irreversible electroporation and ns pulse, and give full play to the advantages of non-thermal treatment of tumor by pulsed electric field, the high frequency ns pulse train was introduced into the application of ablation of tumor tissue. The thermal effect of this high frequency ns pulse train in biological tissue was studied. The temperature and thermal damage of liver and tumor tissue with a pair of needle electrodes were simulated by multi-parameter finite element method. The applied voltage range is 1kV, the pulse width is 50kHz, the repetition rate is between 100k Hz~1 MHz, the length of the pulse string is 100ms, and the repetition rate of the train is 1Hz. The temperature under electrothermal coupling is calculated by using the Pennes bio-heat transfer equation. The thermal damage was calculated by Arrhenius formula. The results showed that the maximum temperature of tumor was 49.26 鈩，

本文编号：1537811