肝癌组织中COX-2蛋白表达及其与临床病理关系的Meta分析

发布时间：2018-02-26 16:38

  本文关键词： 环氧化酶-2 肝癌 病理分化 Meta分析　出处：《青岛大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:通过Meta分析评估环氧化酶-2(COX-2)在肝癌中的表达及其与临床病理特征间的关系,以期寻找肝癌诊断、化学预防及治疗的新型分子靶点。方法:通过检索CNKI、万方、Cochrane图书馆、Pub Med等数据库,搜集从建库至2016.10国内外公开发表的有关COX-2在肝癌中表达的病例对照研究,纳入采用免疫组化法检测COX-2蛋白,并将染色范围及染色强度相结合评估其表达水平,且NOS评分量表≥5分的高质量研究。应用Rev Man5.3进行系统评价及异质性分析,计算合并OR及95%CI,对存在异质性的研究进行亚组分析以探讨其来源,应用Stata12.0绘制漏斗图及Egger回归方程评估有无发表偏倚。结果:共有21篇文献纳入本次系统评价,Meta分析结果显示:COX-2在肝癌组中的表达高于正常组(OR=15.69,95%CI=9.73~25.32,P0.00001);COX-2在癌旁组中的表达高于正常组(OR=9.47,95%CI=4.70~19.10,P0.00001);COX-2在高-中分化肝癌组的表达高于低分化组(OR=1.79,95%CI=1.31~2.46,P=0.0003),差异均具有显著性;在COX-2与性别、肿瘤大小、TNM分期等其他9项HCC临床病理特征关系的比较中,各组间差异并无统计学意义。结论:COX-2在肝癌及癌旁组织中表达增高,且主要在肝癌发生的早期阶段而非进展阶段发挥作用。
[Abstract]:Objective: to evaluate the expression of cyclooxygenase-2 (COX-2) in hepatocellular carcinoma (HCC) and its relationship with clinicopathological features by Meta analysis in order to find out the diagnosis of HCC. Methods: a new molecular target for chemoprevention and therapy. Methods: by searching the database of Med and Pub Med, we collected the case control studies on the expression of COX-2 in liver cancer published from the establishment of the library to the year 2016.10. The expression level of COX-2 protein was evaluated by immunohistochemical method, and the expression level was evaluated by combining the staining range and the staining intensity. The Rev Man5.3 was used for systematic evaluation and heterogeneity analysis, and the NOS score was 鈮，

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