恩度联合紫杉醇对三阴型乳腺癌移植瘤的影响

发布时间：2018-02-27 03:18

本文关键词： 三阴型乳腺癌血管正常化恩度紫杉醇　出处：《暨南大学学报(自然科学与医学版)》2017年06期 　论文类型：期刊论文

【摘要】：目的:通过观察人三阴型乳腺癌在裸鼠模型中血管正常化后对紫杉醇的反应,探讨其疗效是否优于紫杉醇.方法:将人三阴型乳腺癌MDA-MB-231细胞株种植于BALB/c-nu雌裸鼠右下腹部皮下,随机将符合入组标准的28只移植瘤荷鼠分成4组,每组7只,A组,每天每次腹腔内注射生理盐水(质量分数10 mg/kg),连续17 d;B组,每天每次腹腔注射恩度(质量分数10 mg/kg),连续17 d;C组,第6、12天腹腔注射紫杉醇(质量分数10 mg/kg),余同A组;D组,第6、12天腹腔注射紫杉醇(质量分数10 mg/kg),余同B组.测量移植瘤的长径和短径,进行病理学检测.结果:D组移植瘤体积小于A组、B组(P0.05),C组移植瘤体积小于A组及B组(P0.05),D组和C组移植瘤体积无差别(P=0.436).B组、C组、D组的抑瘤率分别是14.61%、39.08%、54.79%.解剖各组荷鼠未见远处转移病灶.病理检查微血管密度,D组C组=B组A组.Ki67,D组与C组A组与B组,D组与C组无差别(P=0.649).结论:使用恩度后在时间窗内联合紫杉醇有明显抑瘤作用,但疗效未优于紫杉醇.
[Abstract]:Objective: to observe the response of human three-negative breast cancer to paclitaxel after vascular normalization in nude mice. Methods: human three-negative breast cancer MDA-MB-231 cell line was implanted into the right lower abdomen of BALB/c-nu female nude mice. Twenty-eight transplanted tumor grafts were randomly divided into 4 groups (n = 7 in each group). Normal saline was injected intraperitoneally every day (10 mg 路kg ~ (-1) 路kg ~ (-1)) in group B for 17 days. Every day (10 mg 路kg ~ (-1) 路kg ~ (-1)) intraperitoneal injection of paclitaxel (10 mg 路kg ~ (-1) 路kg ~ (-1)) (mass fraction 10 mg 路kg ~ (-1)) was performed in group C for 17 days, and paclitaxel (10 mg / kg) was injected intraperitoneally on the 6th day. Paclitaxel (mass fraction 10 mg / kg) was injected intraperitoneally on day 6, 12. The long and short diameters of transplanted tumors were measured. Results the volume of transplanted tumor in group D was smaller than that in group A and group B (P 0.05). There was no difference in the volume of transplanted tumor between group D and group C. The tumor inhibition rate of group C was 14.6139.085.The tumor suppression rate of group C was 14.619.085.The tumor volume of group B was less than that of group A and group B. The tumor volume of group C was less than that of group A and group B, and the volume of group C was less than that of group C. The tumor suppression rate of group C was 14.6139.08 and that of group C was 54.79, respectively. No distant metastases were found. Pathological examination of microvessel density in group C, group B, group A, group B, group C, group A, group B, group A, group B, group A, group B, group A, group B, group A, group B, group A, group B, group A, group B, group C, group A, group D, group C, no difference between P0. 649 and group C. conclusion: the combination of paclitaxel in time window has a significant effect on tumor inhibition. But the curative effect was not better than paclitaxel.
【作者单位】：暨南大学附属第一医院乳腺外科;暨南大学附属第一医院影像学科;暨南大学附属第一医院胃肠外科;暨南大学附属第一医院病理科;
【基金】：国家自然科学基金资助项目(81472849)
【分类号】：R737.9

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