百合类方改善肿瘤相关性抑郁、焦虑的临床研究

发布时间：2018-02-27 11:55

本文关键词： 百合类方肿瘤抑郁焦虑临床研究　出处：《湖北中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:本研究通过了解恶性肿瘤患者抑郁、焦虑情况,探讨百合类方治疗肿瘤相关性抑郁、焦虑的疗效,为中医药在临床治疗改善恶性肿瘤患者心理状态提供参考。方法:将203例恶性肿瘤相关性抑郁、焦虑的患者随机分为2组,对照组给予心理疏导疗法,观察组在心理疏导的基础上,根据患者辨证分型,分别给予百合类方加减治疗。通过向患者发放抑郁自评量表(SDS)和焦虑自评量表(SAS),评价患者焦虑和抑郁情况。发放生活质量核心问卷30个条目(EORTC QLQ—C30)量表,评估患者生活质量,其中诊断为轻度肿瘤相关性抑郁患者67例,中度19例,重度4例。诊断为轻度肿瘤相关性焦虑患者74例,中度33例,重度6例。所有病例根据对照组及观察组所诉方法,连续治疗2个疗程(14天为一个疗程,共28天),于治疗的第1天,第28天收集临床数据。统计学数据采用SPSS 23.0软件包进行分析,结果以均数土标准差(?X土s)表示。观察组与对照组之间比较采用T检验,P0.05表示有统计学意义。结果:研究结果显示:肿瘤相关性抑郁及焦虑的患者经28天治疗后对照组仅情绪功能单项评分较治疗前提高,差异有统计学意义(P0.01)。观察组在躯体功能、情绪功能及总体生活质量评分均较治疗前提高,差异有统计学意义(P0.05或P0.01),与对照组相比,观察组的躯体功能、情绪功能及总体生活质量评分均高于对照组,差异有统计学意义(P0.05或P0.01)。治疗第28天,对照组3个主要症状领域量表评分均无改善,差异无统计学意义(PO.05),观察组疲乏、恶心呕吐单项评分均较治疗前降低,差异有统计学意义(P0.05或P0.01),且低于对照组,差异有统计学意义(P0.05或P0.01)。治疗第28天,对照组6个单项领域量表评分均无改善,差异无统计学意义(P0.05),观察组在失眠、食欲减弱、便秘、腹泻单项评分均较治疗前降低,差异有统计学意义(P0.05或P0.01),且低于对照组,差异有统计学意义(P0.05或P0.01)。治疗第28天,2组SDS及SAS评分均较治疗前有所降低,差异有统计学意义(P0.01)。观察组SDS及SAS评分改善优于对照组,差异有统计学意义(P0.05或P0.01)。结论:百合类方能在一定程度上改善恶性肿瘤相关性抑郁及焦虑患者的抑郁、焦虑情绪,提高患者的生活质量,改善睡眠、饮食、消化等相关症状。对肿瘤相关性抑郁及焦虑状态的干预有效。
[Abstract]:Objective: to investigate the efficacy of Liliangfang in the treatment of tumor-related depression and anxiety by investigating the depression and anxiety in patients with malignant tumor. Methods: 203 patients with malignant tumor-associated depression and anxiety were randomly divided into two groups. On the basis of psychological guidance, the observation group was classified according to the syndrome differentiation of the patients. The patients' anxiety and depression were evaluated by self-rating depression scale (SDS) and self-rating anxiety scale (SAS), and the quality of life was evaluated by issuing 30 items of core questionnaire of quality of life (EORTC QLQ-C30). Among them, 67 cases were diagnosed as mild tumor-associated depression, 19 cases as moderate, 4 cases as severe. 74 cases were diagnosed as mild tumor-associated anxiety, 33 cases as moderate, 6 cases as severe. The clinical data were collected on the first day and the 28th day of treatment. The statistical data were analyzed by SPSS 23.0 software package. Results: the results showed that the patients with tumor-related depression and anxiety were only emotional function sheet after 28 days of treatment. Item score was higher than that before treatment. The scores of somatic function, emotional function and total quality of life in the observation group were higher than those before treatment, and the difference was statistically significant (P0.05 or P0.01). Compared with the control group, the somatic function of the observation group was higher than that of the control group. The scores of emotional function and total quality of life were significantly higher than those of the control group (P 0.05 or P 0.01). On the 28th day of treatment, the scores of the three main symptom areas in the control group were not improved, and the difference was not statistically significant. The single score of nausea and vomiting was lower than that before treatment, the difference was statistically significant (P 0.05 or P 0.01), and the difference was lower than that of the control group (P 0.05 or P 0.01). On the 28th day of treatment, the scores of the six single field scales in the control group were not improved. There was no significant difference (P 0.05). The single score of insomnia, decreased appetite, constipation and diarrhea in the observation group was significantly lower than that before treatment (P 0.05 or P 0.01), and was lower than that in the control group. On the 28th day of treatment, the scores of SDS and SAS in the two groups were lower than those before treatment, and the difference was statistically significant (P 0.01). The improvement of SDS and SAS scores in the observation group was better than that in the control group. Conclusion: lily prescription can improve the depression and anxiety of patients with malignant tumor-related depression and anxiety to a certain extent, improve the quality of life of patients, improve sleep, diet, etc. Digestion and other related symptoms. Tumor-related depression and anxiety state intervention is effective.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R730.5

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