胃癌组织HIF-lα、GLUT-1及LDH-5的表达及其与临床病理特征的关系

发布时间：2018-03-03 07:07

  本文选题：胃癌　切入点：癌旁组织　出处：《四川大学学报(医学版)》2017年01期 　论文类型：期刊论文

【摘要】：目的探讨缺氧诱导因子-1α(HIF-1α)、葡萄糖转运蛋白-1(GLUT-1)及乳酸脱氢酶-5(LDH-5)在胃癌中表达的临床病理意义。方法收集2014年3月至2015年9月贵州省人民医院胃肠外科临床资料完整的手术切除并经病理确诊为腺癌组织的胃癌标本82例(实验组)。男42例,女40例。年龄19~77岁,平均64岁。Ⅰ~Ⅱ期44例,Ⅲ~Ⅳ期38例。同时取其胃癌旁组织作为对照组(82例)。采用免疫组化SP法检测胃癌组织及其癌旁组织中HIF-1α、GLUT-1及LDH-5蛋白的表达,分析其与临床病理特征的关系。结果HIF-1α、GLUT-1及LDH-5在胃癌组织的表达率分别约为78.05%(64/82)、75.61%(62/82)及68.29%(56/82),与癌旁组织的表达率比较,其差异均有统计学意义(P0.01)。胃癌组织中HIF-1α、GLUT-1及LDH-5的阳性表达率与淋巴结转移、肿瘤分化程度和病理分期有相关性(P均0.05);胃癌中HIF-1α、GLUT-1和LDH-5的表达两两之间呈正相关(P0.05)。结论 HIF-1α、GLUT-1及LDH-5在胃癌组织高度表达且与部分临床病理特征有关,或可考虑作为胃癌的诊断、治疗及预后的指标。
[Abstract]:Objective to investigate the clinicopathological significance of the expression of hypoxia-inducible factor-1 伪 (HIF-1 伪), glucose transporter (GLUT-1) and lactate dehydrogenase (LDH-5) in gastric cancer. Methods from March 2014 to September 2015, the clinical data of gastrointestinal surgery in Guizhou Provincial people's Hospital were collected. Methods Eighty-two gastric cancer specimens were surgically resected and pathologically diagnosed as adenocarcinoma (experimental group, n = 42, male, n = 42). There were 40 females aged 19 to 77 years, with an average age of 64 years. 44 cases of stage 鈪，

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