EAS法评估PPI联合黏膜保护剂对ESD术后溃疡愈合的影响

发布时间：2018-03-04 11:47

本文选题：内镜黏膜下剥离术　切入点：医源性溃疡　出处：《安徽医科大学学报》2017年08期 　论文类型：期刊论文

【摘要】：目的利用计算机视觉测量软件法(EAS)对艾司奥美拉唑联合替普瑞酮治疗内镜黏膜下剥离术(ESD)后溃疡疗效的评价。方法选取69例行胃ESD治疗的患者,随机数字表法分为药物联合组35例、质子泵抑制剂(PPI)组34例。药物联合组给予艾司奥美拉唑联合替普瑞酮治疗,PPI组仅给予艾司奥美拉唑治疗,疗程均为4周。应用EAS法评价两组患者术后2周及术后4周溃疡愈合情况及并发症发生率。结果药物联合组无迟发性出血的发生,两组均未出现术中及术后穿孔。ESD术后2周两组溃疡分期、溃疡面积比较差异无统计学意义;术后4周药物联合组溃疡愈合级别高于PPI组(P0.05),药物联合组溃疡面积小于PPI组(P0.05)。结论艾司奥美拉唑联合替普瑞酮能有效提高ESD术后溃疡愈合的质量,减少术后并发症的发生率。EAS法有利于ESD术后溃疡愈合疗效的评价。
[Abstract]:The purpose of using computer vision measurement software (EAS) of esomeprazole combined with teprenone treatment of endoscopic submucosal dissection (ESD) evaluation after ulcer. Methods 69 cases of gastric ESD treated patients, were randomly divided into combination group of 35 cases, a proton pump inhibitor (PPI) group of 34 cases. The drug combination group was given esomeprazole combined with teprenone treatment, PPI group was given esomeprazole treatment, treatment for 4 weeks. EAS was used to evaluate two groups of patients after 2 weeks and 4 weeks after operation of ulcer healing and complications. Results the drug combination group without delayed hemorrhage,.ESD postoperative perforation in two groups had no intraoperative and postoperative 2 weeks after the two groups of peptic ulcer, the ulcer area had no significant difference; after 4 weeks of drug combination group ulcer healing level is higher than that of PPI group (P0.05), drug combination group ulcer area smaller than group PPI (P0. 05). Conclusion esomeprazole combined with teprone can effectively improve the quality of ulcer healing after ESD and reduce the incidence of postoperative complications..EAS method is beneficial to evaluate the curative effect of ulcer healing after ESD.

【作者单位】：安徽医科大学第一附属医院消化内科;
【基金】：安徽省科技攻关项目(编号:15011d04043)
【分类号】：R735

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