直肠癌远切缘c-myc、k-ras基因表达与术后局部复发的相关性研究

发布时间：2018-03-04 14:39

本文选题：直肠癌　切入点：远端切缘　出处：《山西医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的:探讨c-myc、k-ras基因在直肠癌远端切缘表达与术后局部复发的相关性。方法:从我院2008年至2011年间行直肠癌前切除术(Dixon,TME),具有完整病例、病理资料,且术前未行放化疗的患者中,收集47例术后局部复发的患者作为实验组,随机选取50例术后未复发的患者(随访2年未发现复发)作为对照组,分别提取两组患者石蜡标本中瘤组织、近端切缘组织、远端切缘组织行免疫组化检测。结果:1.两组患者在年龄、性别、肿瘤大小、肿瘤分化程度、T分期及淋巴结转移方面比较,差异均无统计学意义。2.分别比较实验组、对照组的瘤组织、近端切缘组织、远端切缘组织c-myc、k-ras表达情况。1).实验组、对照组的瘤组织、近端切缘组织、远端切缘组织中的k-ras表达情况比较后均无统计学差异(P0.05);2).实验组、对照组的瘤组织、近端切缘组织中c-myc表达情况比较后均无统计学差异(P0.05);而两组远端切缘组织中c-myc表达情况比较,实验组远切缘的表达高于对照组,差异具有统计学意义(P0.05)。结论:c-myc在远切缘中的过度表达与直肠癌术后局部复发存在某种相关性。
[Abstract]:Objective: to investigate the correlation between the expression of c-mycron-ras gene in distal incisal margin of rectal cancer and postoperative local recurrence. Methods: from 2008 to 2011, the patients underwent anterior resection of rectal cancer, with complete cases, pathological data, and no preoperative radiotherapy and chemotherapy, were performed from 2008 to 2011. 47 patients with local recurrence after operation were selected as experimental group and 50 patients without recurrence (no recurrence after 2 years follow up) were randomly selected as control group. Tumor tissue and proximal incisal margin tissue were extracted from paraffin samples of two groups of patients. Results there were no significant differences in age, sex, tumor size, tumor differentiation, T stage and lymph node metastasis between the two groups. There was no significant difference in the expression of c-mycnc-ras in tumor tissues, proximal incisal margin tissues and distal incisal margin tissues in the control group, the control group, the control group, the proximal incisal margin and distal incisal margin tissues (P 0.05), and there was no significant difference between the experimental group and the control group in the expression of k-ras in the tumor tissue, the proximal incisal margin tissue and the distal incisal margin tissue. There was no significant difference in the expression of c-myc in the tumor tissues of the control group and in the proximal incisal margin, but the expression of c-myc in the distal incisal margin of the two groups was higher than that in the control group, and the expression of c-myc in the distal incisal margin of the experimental group was higher than that in the control group. Conclusion there is a correlation between the overexpression of c-myc in the distal margin and the local recurrence of rectal cancer.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R735.37

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