Sprouty2蛋白在胃癌组织中的表达及其意义

发布时间：2018-03-06 23:33

本文选题：胃腺癌　切入点：Sprouty2　出处：《山东大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探索Sprouty2(SPRY2)在胃癌及癌旁组织中的表达情况,分析其表达水平与临床病理因素及患者预后的相关性。方法:采用免疫组织化学的方法检测了 121例胃腺癌标本中Sprouty2的表达。通过卡方检验评估了 SPRY2表达与临床病理因素的相关性,并通过Kaplan-Merier法计算了 SPRY2与总体生存率的关系,即SPRY2的预后意义。通过实时定量PCR的方法,我们检测了 11对肿瘤组织和癌旁正常组织中SPRY2的mRNA水平并加以比较。结果:SPRY2在121例胃癌组织较低表达80例,较高表达41例,胃癌组织SPRY2表达水平较癌旁组织表达量显著降低。通过卡方检验证明SPRY2的表达与淋巴结转移(P0.001)和TNM分期明显相关(P=0.004)。Kaplan-Meier生存分析证明SPRY2低表达组与高表达组的病人存在显著的总体生存率的差异。SPRY2可以作为胃腺癌的一个预后标记物。结论:SPRY2高表达与胃癌病人不良预后明显相关,可作为胃癌预后的评价指标。
[Abstract]:Objective: to investigate the expression of Sprouty2 (SPRY2) in gastric carcinoma and its adjacent tissues. To analyze the correlation between expression level and clinicopathological factors and prognosis. Methods: immunohistochemical method was used to detect the expression of Sprouty2 in 121 cases of gastric adenocarcinoma. The expression of SPRY2 was evaluated by chi-square test. Correlation of pathological factors in bed, The relationship between SPRY2 and overall survival rate was calculated by Kaplan-Merier method, that is, the prognostic significance of SPRY2. The levels of SPRY2 mRNA in 11 pairs of tumor tissues and adjacent normal tissues were detected and compared. Results the expression of SPRY2 in 121 cases of gastric cancer was lower in 80 cases and higher in 41 cases. The expression level of SPRY2 in gastric cancer was significantly lower than that in paracancerous tissues. Chi-square test showed that the expression of SPRY2 was significantly correlated with lymph node metastasis (P0.001) and TNM staging. Kaplan-Meier survival analysis showed that the patients with low SPRY2 expression and high expression had a positive correlation with P0.004. Kaplan-Meier survival analysis. SPRY2 may be used as a prognostic marker in gastric adenocarcinoma. Conclusion the high expression of SPRY2 is associated with the poor prognosis of gastric cancer patients. It can be used as an index to evaluate the prognosis of gastric cancer.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.2

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