锯齿状息肉与传统腺瘤风险因素对比及结直肠癌适宜筛查年龄

发布时间：2018-03-07 13:51

本文选题：锯齿状息肉　切入点：传统腺瘤　出处：《南方医科大学学报》2017年05期 　论文类型：期刊论文

【摘要】：目的对锯齿状息肉(SPs)及传统腺瘤(CA)相关风险因素进行分析、对比,探讨两类息肉风险因素间异同。方法收集南方医院消化内镜中心2012~2015行全结肠镜及息肉病理检查的病例。随机选取健康对照103例,SPs 100例,CA 115例,采集各病例性别、年龄、身高、体质量等临床数据。运用SPSS软件,先对各因素进行组间多重比较,对具有显著性的因素再纳入多因素logistic回归分析,得到风险因素及其OR值。结果 SPs平均发病年龄48.87岁(95%CI 47.22-50.52),较CA更早(P=0.038)。以青年组为参照,中年组发生SPs风险增加2.31倍(95%CI 1.46-3.65)、CA风险增加4.10倍(95%CI 2.50-6.72);老年组发生SPs风险增加2.77倍(95%CI 1.52-5.04)、CA风险增加6.00倍(95%CI 3.26-11.05)。其中,年龄与CA的发生较SPs关系更为密切(老年组:OR=2.14,95%CI 1.21-3.78,P=0.009)。男性较女性SPs发病风险增加2.75倍(95%CI 1.50-5.07)、CA增加2.19倍(95%CI1.22-3.95)。BMI每增加1个单位,SPs发病风险增加1.18倍(95%CI 1.06-1.30)、CA增加1.20倍(95%CI 1.09-1.32)。结论两类息肉风险因素类别相同,可使用同一方案进行高危人群筛查。SPs平均发病年龄早于50岁且有可能快速进展为癌,提早CRC筛查年龄值得考虑。
[Abstract]:Objective to analyze and compare the risk factors associated with serrated polyp (SPS) and traditional adenoma (CA). To explore the similarities and differences between the two types of polyp risk factors. Methods Total colonoscopy and pathological examination of polyps were performed in endoscopy center of digestive tract of Southern Hospital in 20122015. One hundred patients with CA were randomly selected from 103 healthy controls. The sex, age and height of each case were collected. Body mass and other clinical data. By using SPSS software, the factors were compared among groups first, and then the significant factors were included in the multivariate logistic regression analysis. Results the mean age of onset of SPs was 48.87 years old (CI 47.22-50.52), which was earlier than CA. The risk of SPs in middle age group increased by 2.31 times, and the risk of SPs in elderly group increased by 4.10 times and by 2.77 times and 95 times by CI 1.52-5.04. The risk of SPs in middle age group increased by 6.00 times, and increased by 6.00 times with 95% CI 3.26-11.05. Among them, the risk of SPs in the elderly group was increased by 2.77 times and 95 times by 95% CI 1.52-5.04%. The incidence of CA was more closely related to age than that of SPs (in the elderly group, CI 1.21-3.78-CI 1.21-3.78.The risk of SPs in males was 2.75-95 times higher than that in women), and the risk of SPs in males was 2.19-fold higher than that in females. Conclusion there is a 1.18 fold increase in 95 CI 1.06-1.30C 1.09-1.32 for each unit of increase of 95 CI 1.22-3.95. Conclusion there is a 1.20 fold increase in 95 CI 1.09-1.32 for each unit of increase in the risk of CA in the elderly group (1. 1495 CI 1.21-3.78). Conclusion there is a 1.20 fold increase in 95 CI 1.09-1.32 for each unit. Polyp risk factors are the same, We can use the same program to screen the high risk population. The average age of onset of .SPs is earlier than 50 years old and it is possible to develop into cancer quickly. The early age of CRC screening should be considered.
【作者单位】：南方医科大学南方医院消化科//广东省胃肠疾病重点实验室;
【基金】：广东省科技基金(2012B050600020)
【分类号】：R735.34

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