结肠镜检查人群肛门HPV感染情况调查及危险因素研究

发布时间：2018-03-07 16:45

本文选题：人乳头瘤病毒　切入点：肛门　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:本研究旨在研究结肠镜检查人群肛门人类乳头状病毒(Human papillomavirus,HPV)的感染情况,并分析肛门HPV感染的相关危险因素。方法:对2014年11月至2016年11月在新疆医科大学第一附属医院内镜中心行结肠镜检查的273例患者行问卷调查,同时采用肛门刷采集脱落上皮细胞,在显微镜下观察病理改变,HC2法联合基因芯片法行HPV-DNA检测及基因分型。结果:在273例标本中检出HPV-DNA阳性8例,总感染率为2.93%,其中4例为52+58型,2例16型,1例35型,1例39型,均属于高危型HPV,显微镜下观察均未见明显的病理改变。年龄、文化程度、消化道症状是影响肛门HPV感染的危险因素。结论:结肠镜检查人群存在着一定的HPV感染率。年龄、文化程度、消化道症状可能是影响肛门HPV感染的危险因素。
[Abstract]:Objective: to study the infection of human papillomavirus (HPV) in human anal papillomavirus (HPV) by colonoscopy. Methods: from November 2014 to November 2016, 273 patients who underwent colonoscopy in the endoscopic center of the first affiliated Hospital of Xinjiang Medical University were investigated by questionnaire. At the same time, exfoliated epithelial cells were collected by anal brush, and the pathological changes were observed under microscope. HPV-DNA detection and genotyping were performed by using HC2 method and gene chip method. Results: among 273 specimens, 8 cases were positive for HPV-DNA. The total infection rate was 2.93%, of which 4 cases were 52, 58 type, 2 cases, 16 cases, 1 case, 35 type, and 1 case, 39 type, all belonged to high risk type HPV.There were no obvious pathological changes under microscope. Conclusion: there is a certain HPV infection rate in the colonoscopy population. Age, education level and digestive tract symptoms may be the risk factors affecting anal HPV infection.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.38

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